PTPRN Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52202
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | CA 512,FLJ16131,IA 2,IA 2/PTP,IA2,IA2/PTP,ICA 3,ICA 512,ICA3,ICA512,Islet cell antigen 2,Islet cell antigen 512,Islet cell autoantigen 3,Protein tyrosine phosphatase like N,Protein tyrosine phosphatase like N precursor,Protein tyrosine phosphatase receptor type N,PTP IA 2,PTP IA-2,PTP IA2,PTPIA 2,PTPN,Ptprn,PTPRN protein,PTPRN,R PTP N,R-PTP-N,Receptor type tyrosine protein phosphatase like N,Receptor-type tyrosine-protein phosphatase-like N,RPTPN,PTPRN抗体 |
| Swissprot | Q16849 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human PTPRN |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.96mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. Neuroendocrine secretory granules. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family,which contains a transmembrane region,an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker. |
