Purified Anti-Human CD8a Antibody[HIT8a]
| 规格： | / 25μg / 100μg |
| 价格： | / ￥192 / ￥640 |
货号：E-AB-F1271A
货期：咨询
宿主: Mouse
反应性: H
应用: FCM
Overview
| Synonyms | CD8; Leu-2; Ly-2;CD8;CD8 antigen alpha po;CD8 antigen alpha polypeptide;CD8A;Leu;Leu2;MAL;T-cell surface glycoprotein CD8 alpha chain;T-lymphocyte differentiation antigen T8/Leu;T-lymphocyte differentiation antigen T8/Leu-2;T8;alpha polypeptide (p32);p32 |
| Swissprot | P01732 |
| Source | Mouse |
| Reactivity | Human |
| Application | FCM |
| Concentration | 0.5mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | HIT8a |
|---|---|
| Isotype | Mouse IgG1, κ |
| Conjugation | Unconjugated |
| Storage instructions | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Storage buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Background | CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
