Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98]
| 规格： | / 25μg / 100μg |
| 价格： | / ￥400 / ￥768 |
货号：E-AB-F1107A
货期：咨询
宿主: Rat
反应性: M
应用: FCM
Overview
| Synonyms | CD115;CSF-1 receptor (EC:2.7.10.1);CSF-1-R;CSF-1R;Csf1r;Csfmr;Fms;M-CSF-R;Macrophage colony-stimulating factor 1 receptor;Proto-oncogene c-Fms |
| Swissprot | P09581 |
| Source | Rat |
| Reactivity | Mouse |
| Application | FCM |
| Concentration | 0.5mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | AFS98 |
|---|---|
| Isotype | Rat IgG2a, κ |
| Conjugation | Unconjugated |
| Storage instructions | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Storage buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Background | CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. |
