Purified Anti-Mouse CD45R/B220 Antibody[RA3.3A 1/6.1]
| 规格： | / 25μg / 100μg |
| 价格： | / ￥160 / ￥576 |
货号：E-AB-F1112A
货期：咨询
宿主: Rat
反应性: M
应用: FCM
Overview
| Synonyms | B220 |
| Source | Rat |
| Reactivity | Mouse |
| Application | FCM |
| Concentration | 0.5mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | RA3.3A 1/6.1 |
|---|---|
| Isotype | Rat IgM, κ |
| Conjugation | Unconjugated |
| Storage instructions | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Storage buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Background | CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity. |
