Purified Anti-Mouse CD8a Antibody[53-6.7]
| 规格： | / 25μg / 100μg |
| 价格： | / ￥152 / ￥392 |
货号：E-AB-F1104A
货期：咨询
宿主: Rat
反应性: M
应用: FCM
Overview
| Synonyms | CD8A;MAL;T-cell surface glycoprotein CD8 alpha chain;T-lymphocyte differentiation antigen T8/Leu-2 |
| Swissprot | P01731 |
| Source | Rat |
| Reactivity | Mouse |
| Immunogen | Recombinant Mouse CD8a protein |
| Application | FCM |
| Recommended dilution | FCM,,2 μg/mL(1×10^5-5×10^5 cells) |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 53-6.7 |
|---|---|
| Isotype | Rat IgG2a, κ |
| Purification | >98%, Protein A/G purified |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Storage buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Background | CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. |
