Rat IL-1β(Interleukin 1 Beta) ELISA Kit
大鼠白介素1β(IL-1β)酶联免疫吸附测定试剂盒
| 规格： | / 96T / 48T / 96T*5 |
| 价格： | / ￥2400 / ￥1650 / ￥10200 |
货号：E-EL-R0012
反应性: 大鼠
检测范围: 31.25~2000 pg/mL
灵敏度: 18.75 pg/mL
用途
该试剂盒用于体外定量检测大鼠serum, plasma and other biological fluids中IL-1β浓度
检测原理
本试剂盒采用双抗体夹心ELISA法。用抗大鼠IL-1β抗体包被于酶标板上，实验时样品或标准品中的大鼠IL-1β会与包被抗体结合，游离的成分被洗去。依次加入生物素化的抗大鼠IL-1β抗体和辣根过氧化物酶标记的亲和素。抗大鼠IL-1β抗体与结合在包被抗体上的大鼠IL-1β结合、生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。加入显色底物(TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。用酶标仪在450nm波长处测OD值，IL-1β浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中IL-1β的浓度。
| 反应类型 | 夹心法 |
| 规格 | 96T |
| 反应时间 | 3.5h |
| 反应性 | 大鼠 |
| 检测方法 | Colormetric |
| 检测范围 | 31.25—2000 pg/mL |
| 灵敏度 | 18.75 pg/mL |
| 样本体积 | 100μL |
| 样本类型 | serum, plasma and other biological fluids |
特异性
可检测样本中的大鼠IL-1β，且与其它相关蛋白无明显交叉反应。
重复性
板内，板间变异系数均<10%。
典型数据
由于实验操作条件的不同（如操作者、移液技术、洗板技术和稳定条件等），标准曲线的OD值会有所差异。以下数据和曲线仅供参考，实验者需根据自己的实验建立标准曲线。
| (pg/mL) | O.D | Average | Corrected |
|---|---|---|---|
| 2000 | 2.388 2.442 |
2.415 | 2.349 |
| 1000 | 1.602 1.622 |
1.612 | 1.546 |
| 500 | 0.956 0.940 |
0.949 | 0.883 |
| 250 | 0.494 0.53 |
0.512 | 0.446 |
| 125 | 0.266 0.242 |
0.254 | 0.188 |
| 62.5 | 0.169 0.163 |
0.166 | 0.1 |
| 31.25 | 0.114 0.122 |
0.118 | 0.052 |
| 0 | 0.06 0.070 |
0.066 | -- |
精密度
板内精密度:低浓度样本,中浓度样本和高浓度样本分别在1块板子上检测20次。
板间精密度:低浓度样本,中浓度样本和高浓度样本分别在3块板子上检测20次。
| Intra-assay Precision | Inter-assay Precision | |||||
|---|---|---|---|---|---|---|
| Sample | 1 | 2 | 3 | 1 | 2 | 3 |
| n | 20 | 20 | 20 | 20 | 20 | 20 |
| Mean (pg/mL) |
100.50 | 314.20 | 880.10 | 107.40 | 340.60 | 954.80 |
| Standard
deviation |
5.70 | 13.50 | 30.80 | 5.60 | 20.40 | 33.40 |
| C V (%) | 5.67 | 4.30 | 3.50 | 5.21 | 5.99 | 3.50 |
回收率
分别往5个不同样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围和平均回收率。
| Sample Type | Range (%) | Average Recovery (%) |
|---|---|---|
| Serum (n=5) | 85-98 | 91 |
| EDTA plasma (n=5) | 86-100 | 93 |
| Cell culture media (n=5) | 86-101 | 92 |
线性
分别往5个样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围及平均回收率。将5个样本分别稀释2倍，4倍，8倍，16倍做回收实验，得出回收率范围及平均回收率。
| Serum (n=5) | EDTA plasma (n=5) | Cell culture media (n=5) | ||
|---|---|---|---|---|
| 1:2 | Range (%) | 86-100 | 86-96 | 100-116 |
| Average (%) | 92 | 91 | 106 | |
| 1:4 | Range (%) | 95-105 | 84-96 | 94-106 |
| Average (%) | 100 | 91 | 100 | |
| 1:8 | Range (%) | 101-114 | 81-91 | 96-112 |
| Average (%) | 108 | 86 | 103 | |
| 1:16 | Range (%) | 96-108 | 83-97 | 92-106 |
| Average (%) | 102 | 89 | 99 |
试剂盒组成及保存
未拆封的试剂盒可在4℃保存一周；如果一周以后才使用试剂盒，请拆开试剂盒按照下表中的条件分别保存各组分。
| 中文名称 | 英文名称 | 规格 | 保存条件 |
|---|---|---|---|
| ELISA酶标板(可拆卸) | Micro ELISA Plate(Dismountable) | 8 孔×12 条 | -20℃，可存放6个月 |
| 冻干标准品 | Reference Standard | 2 支 | |
| 浓缩生物素化抗体(100×) | Concentrated Biotinylated Detection Ab | 1支 120 μL | |
| 浓缩HRP酶结合物(100×) | Concentrated HRP Conjugate | 1支 120 μL | -20℃(避光)，可存放6个月 |
| 标准品&样品稀释液 | Reference Standard & Sample Diluent | 1瓶 20 mL | 4℃.可存放6个月 |
| 生物素化抗体稀释液 | Biotinylated Detection Ab Diluent | 1瓶 14 mL | |
| 酶结合物稀释液 | HRP Conjugate Diluent | 1瓶 14 mL | |
| 浓缩洗涤液(25×) | Concentrated Wash Buffer (25×) | 1瓶 30 mL | |
| 底物溶液(TMB) | Substrate Reagent | 1瓶 10 mL | 4℃(避光) |
| 反应终止液 | Stop Solution | 1瓶 10 mL | 4℃ |
| 封板覆膜 | Plate Sealer | 5 张 | |
| 产品说明书 | Product Description | 1 份 | |
| 质检报告 | Certificate of Analysis | 1 份 |
说明：所有试剂瓶盖须旋紧以防止蒸发和微生物的污染。
试剂体积以实际发货版说明书为准。相关试剂在分装时会比标签上标明的体积稍多一些，请在使用时量取而非直接倒出。
试验所需自备物品
- 1. 酶标仪(450nm波长滤光片)
- 2. 高精度移液器，EP管及一次性吸头：0.5-10 μL, 2-20 μL, 20-200 μL, 200-1000 μL
- 3. 37℃恒温箱，双蒸水或去离子水
- 4. 吸水纸
操作步骤
|
|
1.对应板孔中加入100μL标准品工作液或样本，37℃孵育90分钟 |
| 2.弃掉板内液体后，立即加入100μL生物素化抗体工作液，37℃孵育60分钟 | |
| 3.弃掉板内液体，洗板3次 | |
| 4.每孔加入100μL HRP酶结合物工作液，37℃孵育30分钟，弃掉板内液体，洗板5次 | |
| 5.每孔加入90μL底物溶液，37℃孵育15分钟 | |
| 6.每孔加入50μL终止液 | |
| 7.立即在450nm波长下读数，处理数据 |
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样品类型: Cell culture supernatant - 文献: Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats
样品类型: serum - 文献: Nicotinamide mononucleotide attenuates doxorubicin-induced cardiotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
样品类型: plasma, heart - 文献: Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress
样品类型: Serum,Bronchoalveolar Lavage Fluid,Tissue homogenate - 文献: Win55,212-2 Improves Neural Injury induced by HIV-1 Glycoprotein 120 in Rats by Exciting CB2R
样品类型: hippocampus - 文献: MSCs ameliorates DPN induced cellular pathology via [Ca2+]i homeostasis and scavenging the pro‐inflammatory cytokines
样品类型: neuronal cell - 文献: Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats
样品类型: Serum,ovarian cell - 文献: MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression
样品类型: Tissue homogenate,Cell culture supernatant - 文献: Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats
样品类型: Serum,Tissue homogenate - 文献: hUC-MSCs exosomal miR-451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF-PI3K-AKT signaling pathway
样品类型: serum,NR8383 cell - 文献: Platelet-rich plasma exhibits anti-inflammatory effect and attenuates cardiomyocyte damage by reducing NF-κB and enhancing VEGF expression in isoproterenol induced cardiotoxicity model
样品类型: cardiac tissue - 文献: LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway
样品类型: bronchoalveolar lavage fluid (BALF) - 文献: Limonin ameliorates acute pancreatitis by suppressing JAK2/STAT3 signaling pathway
样品类型: serum - 文献: Iron-induced cellular in vitro neurotoxic responses in rat C6 cell line
样品类型: glioma C6 cell - 文献: Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats
样品类型: serum - 文献: 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide
样品类型: serum - 文献: Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling
样品类型: blood - 文献: MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2
样品类型: serum - 文献: Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway
样品类型: brain - 文献: 3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and abating DNA damage
样品类型: Hepatic,renal - 文献: Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability
样品类型: Bronchoalveolar Lavage Fluid - 文献: Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells
样品类型: plasma - 文献: The role of Ca 2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis
样品类型: Plasma - 文献: Sodium para-aminosalicylic acid ameliorates brain neuroinflammation and behavioral deficits in juvenile lead-exposed rats by modulating MAPK signaling pathway and alpha-synuclein
- 文献: Alpha-Chymotrypsin Protects Against Acute Lung, Kidney, and Liver Injuries and Increases Survival in CLP-Induced Sepsis in Rats Through Inhibition of TLR4/NF-κB Pathway
样品类型: serum - 文献: Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology
样品类型: serum - 文献: Network pharmacology analysis uncovers the effect on apoptotic pathway by Bu-Fei formula for COPD treatment
样品类型: bronchoalveolar lavage fluid (BALF) - 文献: Nephroprotective mechanisms of Ambrette (Abelmoschus moschatus Medik.) leaf extracts in adriamycin mediated acute kidney injury model of Wistar rats
样品类型: Kidney - 文献: Integrated serum pharmacochemistry and network pharmacological analysis used to explore possible anti-rheumatoid arthritis mechanisms of the Shentong-Zhuyu decoction
样品类型: Serum - 文献: Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway
样品类型: retinal tissue - 文献: Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways
样品类型: serum - 文献: Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model
样品类型: Serum - 文献: Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier
样品类型: Tissue homogenate - 文献: BMSC-EVs overexpressing PD-L1 ameliorate DSS-induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis
样品类型: blood,colon - 文献: Protective effect of ethanolic extract of Echinacea purpurea contained nanoparticles on meniscal/ligamentous injury induced osteoarthritis in obese male rats
样品类型: plasma - 文献: Low-intensity low-frequency pulsed ultrasound ameliorates sciatic nerve dysfunction in a rat model of cisplatin-induced peripheral neuropathy
样品类型: serum - 文献: Chondroitin and glucosamine sulphate reduced proinflammatory molecules in the DRG and improved axonal function of injured sciatic nerve of rats
样品类型: dorsal root ganglia - 文献: Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways
样品类型: serum - 文献: The Potential Antipyretic Mechanism of Ellagic Acid with Brain Metabolomics Using Rats with Yeast-Induced Fever
样品类型: serum - 文献: Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats
样品类型: hippocampus - 文献: Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism
样品类型: brain,blood plasma - 文献: Sodium Para-aminosalicylic Acid Inhibits Lead-Induced Neuroinflammation in Brain Cortex of Rats by Modulating SIRT1/HMGB1/NF-κB Pathway
样品类型: primary cortical neurons - 文献: Periodontitis exacerbates the renal degenerative effects of obesity in rats
样品类型: kidney - 文献: Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats
样品类型: hippocampus tissue - 文献: Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-κB signalling pathway
样品类型: serum,sciatic nerves - 文献: PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis
样品类型: serum - 文献: Piperazine ferulate protects against cardiac ischemia/reperfusion injury in rat via the suppression of NLRP3 inflammasome activation and pyroptosis
样品类型: serum - 文献: The impact of Sambucus nigra L. extract on inflammation, oxidative stress and tissue remodeling in a rat model of lipopolysaccharide-induced subacute rhinosinusitis
样品类型: Serum - 文献: TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation
样品类型: serum - 文献: Exploring the role of Aquaporins (AQPs) in LPS induced systemic inflammation and the ameliorative effect of Garcinia in male Wistar rat
样品类型: serum - 文献: BML-111 inhibits osteoclast differentiation by suppressing the MAPK and NF-κB pathways, alleviating deterioration of the knee joints in a CIA rat model
样品类型: serum - 文献: Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis
样品类型: Plasma - 文献: C1q/TNF‐related protein‐9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction
样品类型: Tissue homogenate - 文献: Selenium abates manganese–induced striatal and hippocampal toxicity via abrogation of neurobehavioral deficits, biometal accumulation, oxidative stress, inflammation, and caspase-3 activation in rats
样品类型: striatum,hippocampus - 文献: Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats
样品类型: Serum - 文献: Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway
样品类型: Serum - 文献: Effects of Atractylodes Oil on Inflammatory Response and Serum Metabolites in Adjuvant Arthritis Rats
样品类型: serum - 文献: Diacerein protects rats with liver ischemia/reperfusion damage: Down-regulation of TLR4/ NFκ-B signaling pathway
样品类型: Tissue homogenate - 文献: Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota
样品类型: Tissue homogenate - 文献: MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1)
样品类型: H9C2 cell - 文献: Study of double-targeting nanoparticles loaded with MCL-1 siRNA and dexamethasone for adjuvant-induced arthritis therapy
样品类型: Serum - 文献: Quercetin and Its Derivative Counteract Palmitate-Dependent Lipotoxicity by Inhibiting Oxidative Stress and Inflammation in Cardiomyocytes
样品类型: H9c2 cardiomyocytes - 文献: C/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling
样品类型: NR8383 cell - 文献: Hyperbaric Oxygen Intervention Modulates Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats: Possible Involvement of TLR4/NF-κ B-Mediated Signaling Pathway
样品类型: Tissue homogenate - 文献: Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury
样品类型: lung tissue - 文献: Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study
样品类型: knee articular tissue - 文献: CTRP9 Ameliorates Atrial Inflammation, Fibrosis, and Vulnerability to Atrial Fibrillation in Post‐Myocardial Infarction Rats
样品类型: left atria - 文献: Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain
样品类型: Plasma - 文献: Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD
样品类型: Tissue homogenate,Bronchoalveolar Lavage Fluid - 文献: Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation
样品类型: BV-2 cells - 文献: Effects of different simulated submarine escape depths by free ascent in animal models
样品类型: Serum - 文献: Effect of Celecoxib and Infliximab against Multiple Organ Damage Induced by Sepsis in Rats: A Comparative Study
样品类型: Serum - 文献: Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain
样品类型: cortex,hippocampus - 文献: Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis
样品类型: Cell culture supernatant,Tissue homogenate - 文献: N-acetyl cysteine abates hepatorenal toxicities induced by perfluorooctanoic acid exposure in male rats
样品类型: Serum,Tissue homogenate - 文献: Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo
样品类型: serum,LV(left ventricular) myocardium,H9c2 cells - 文献: Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: The regulation of autophagy and ROS production
样品类型: Serum - 文献: Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects
样品类型: brain - 文献: 7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation
样品类型: serum - 文献: Protective effect of mirtazapine against acetic acid-induced ulcerative colitis in rats: Role of NLRP3 inflammasome pathway
样品类型: colonic tissue - 文献: Pinocembrin inhibited cardiomyocyte pyroptosis against doxorubicin-induced cardiac dysfunction via regulating Nrf2/Sirt3 signaling pathway
样品类型: Serum,Cell culture supernatant - 文献: Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway
样品类型: serum,Cell culture supernatant(THP-1 cells) - 文献: Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway
样品类型: brain - 文献: 25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy
样品类型: Serum - 文献: Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro
样品类型: Cell culture supernatant,Tissue homogenate - 文献: Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome
样品类型: serum - 文献: TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling
样品类型: retinas - 文献: Immunomodulatory activity of extracts from five edible basidiomycetes mushrooms in Wistar albino rats
样品类型: serum - 文献: Curative effect and mechanisms of Radix Arnebiae oil on burn wound healing in rats
样品类型: burn wound tissue - 文献: Ulinastatin reduces myocardial injury induced by doxorubicin in SD rats.
样品类型: Serum - 文献: The effect of myocardial infarction-associated transcript 2 (Mirt2) and miR-101 on sepsis-induced myocardial injury in rats.
样品类型: Serum - 文献: Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in podocytes via sponging miRNA-302b-3p to upregulate TIMP3
样品类型: Serum - 文献: Curcumin exerts protective effect on PC12 cells against lidocaine-induced cytotoxicity by suppressing the formation of NLRP3 inflammasome.
样品类型: Cell culture supernatant - 文献: Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B1
样品类型: liver,kidney - 文献: Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes
样品类型: Cell culture supernatant - 文献: The novel estrogen receptor GPER1 decreases epilepsy severity and susceptivity in the hippocampus after status epilepticus
样品类型: Hippocampus - 文献: Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain
样品类型: spinal cord - 文献: Morroniside alleviates coxsackievirus B3-induced myocardial damage apoptosis via restraining NLRP3 inflammasome activation
样品类型: Tissue homogenate - 文献: DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway
样品类型: Hippocampal tissue - 文献: Venenum Bufonis induces rat neuroinflammation by activiating NF-κB pathway and attenuation of BDNF
样品类型: Tissue homogenate - 文献: Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways
样品类型: Serum - 文献: Platelet-rich plasma and/or sildenafil topical applications accelerate and better repair wound healing in rats through regulation of proinflammatory cytokines and collagen/TGF-β1 pathway
样品类型: Serum - 文献: Aged garlic extract rescues ethephon-induced kidney damage by modulating oxidative stress, apoptosis, inflammation, and histopathological changes in rats
样品类型: Serum - 文献: Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors
样品类型: Plasma,Tissue homogenate - 文献: Hyaluronic Acid Coated Acid-Sensitive Nanoparticles for Targeted Therapy of Adjuvant-Induced Arthritis in Rats
样品类型: Serum - 文献: Neurobehavioural and biochemical responses associated with exposure to binary waterborne mixtures of zinc and nickel in rats
样品类型: cerebellum,cerebrum,liver - 文献: Curcumin combined with Baicalin attenuated ethanol-induced hepatitis by suppressing p38 MAPK and TSC1/ eIF-2α/ATF4 pathways in rats
样品类型: liver tissue lysate - 文献: Anti-inflammatory activity of 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid in LPS-induced rat model
样品类型: Plasma - 文献: Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines
样品类型: Serum - 文献: Scopoletin‐standardized Morinda elliptica leaf extract suppressed inflammation and cartilage degradation to alleviate osteoarthritis: A preclinical study
样品类型: Serum - 文献: Holistic and dynamic metabolic alterations of traditional Chinese medicine syndrome in a toxic heat and blood stasis syndrome rat model
样品类型: plasma - 文献: β-arrestin2 Mediates the Arginine Vasopressin-Induced Expression of IL-1β in Murine Hearts
样品类型: Adult rat cardiac fibroblasts (ARCFs) - 文献: H2S attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty:
样品类型: Plasma - 文献: Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis
样品类型: serum - 文献: STING mediates SU5416/hypoxia-induced pulmonary arterial hypertension in rats by regulating macrophage NLRP3 inflammasome activation
样品类型: lung tissues,Bone marrow-derived macrophage (BMDMs) - 文献: Acute aflatoxin B 1 -induced gastro-duodenal and hepatic oxidative damage is preceded by time-dependent hyperlactatemia in rats
样品类型: Serum - 文献: Associations of inflammatory markers and vascular cell adhesion molecule-1 with endothelial dysfunction in collagen-induced arthritis
样品类型: Serum - 文献: Small Molecule Inhibiting Nuclear Factor‐kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan‐Induced Diabetic Nephropathy in Rat
样品类型: Tissue homogenate - 文献: Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation
样品类型: serum - 文献: Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway
样品类型: Cell culture supernatant,Tissue homogenate - 文献: Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke
样品类型: Tissue homogenate - 文献: Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata, in Ovariectomy-Induced Osteoporotic Rats
样品类型: Serum - 文献: Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis
样品类型: Tissue homogenate - 文献: The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways
样品类型: Bronchoalveolar Lavage Fluid,Serum,Tissue homogenate - 文献: Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation
样品类型: heart tissue - 文献: The IL-6/HO-1/STAT3 signaling pathway is implicated in the amelioration of acetaminophen-induced hepatic toxicity: A neonatal rat model
样品类型: hepatic - 文献: Ferulic Acid Treats Gastric Ulcer via Suppressing Oxidative Stress and Inflammation
样品类型: gastric tissue - 文献: Celastrol mitigates high glucose‐induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR‐345‐5p/growth arrest‐specific 6
样品类型: H9c2 cell - 文献: Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats
样品类型: Tissue homogenate - 文献: Neuroprotection by luteolin and gallic acid against cobalt chloride-induced behavioural, morphological and neurochemical alterations in Wistar rats
样品类型: serum - 文献: Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation
样品类型: Tissue homogenate(Hippocampal tissues) - 文献: Protective effects of Ulinastatin on oxidative stress and inflammation of rat-derived cardiomyocytes H9c2
样品类型: H9c2 cells - 文献: Dehydroevodiamine Suppresses Inflammatory Responses in Adjuvant-Induced Arthritis Rats and Human Fibroblast-Like Synoviocytes
样品类型: serum,MH7A cells - 文献: Protective effect of Ganoderic acid A on adjuvant-induced arthritis
样品类型: Serum - 文献: Metformin attenuates sepsis-induced neuronal injury and cognitive impairment
样品类型: hippocampus tissue - 文献: Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance
样品类型: Serum - 文献: Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis
样品类型: Serum - 文献: Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells
样品类型: Serum,Cell culture supernatant,Tissue homogenate - 文献: SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy
样品类型: Tissue homogenate - 文献: prevented osteoarthritis cartilage degeneration by attenuating joint inflammation and collagen breakdown in postmenopausal rat model
样品类型: serum - 文献: ) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study
样品类型: serum - 文献: Nanostructured fibrin agarose hydrogel as a novel haemostatic agent
样品类型: Plasma - 文献: Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis
样品类型: Serum,amygdala - 文献: Impact of improving eating habits and rosmarinic acid supplementation on rat vascular and neuronal system in the metabolic syndrome model
样品类型: Serum - 文献: Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment
样品类型: Tissue homogenate - 文献: Rupatadine protects the intestinal mucosa from injury by 5-flurouracil via modulation of inflammation, apoptosis and intestinal permeability
样品类型: intestinal - 文献: The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats
样品类型: Tissue homogenate - 文献: Inhibition of macrophage migration inhibitory factor attenuates inflammation and fetal kidney injury in a rat model of acute pancreatitis in pregnancy
样品类型: Serum - 文献: Effect of Clostridium butyricum and Butyrate on Intestinal Barrier Functions: Study of a Rat Model of Severe Acute Pancreatitis With Intra-Abdominal Hypertension
样品类型: Plasma - 文献: Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response
样品类型: Tissue homogenate - 文献: CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats
样品类型: spinal cord tissues - 文献: Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction
样品类型: Tissue homogenate(Bladder) - 文献: Lidocaine activates autophagy of astrocytes and ameliorates chronic constriction injury-induced neuropathic pain
样品类型: astrocyte - 文献: Celastrol Attenuates Learning and Memory Deficits in an Alzheimer’s Disease Rat Model
样品类型: brain - 文献: Evaluation of cytokines in protective effect of docosahexaenoic acid in experimental achilles tendinopathy rat model induced with type-1 collagenase
样品类型: serum - 文献: Adipose‑derived mesenchymal stem cell‑derived HCAR1 regulates immune response in the attenuation of sepsis
样品类型: blood - 文献: Knockdown of ILK Alleviates High Glucose-Induced Damage of H9C2 Cells through TLR4/MyD88/NF-κB Pathway
样品类型: H9C2 cell - 文献: Tao‐Hong‐Si‐Wu decoction reduces ischemia reperfusion rat myoblast cells calcium overloading and inflammation through the Wnt/IP3R/CAMKII pathway
样品类型: Cell culture supernate - 文献: Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats
样品类型: kidney - 文献: Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study
样品类型: Tissue homogenate - 文献: Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity
样品类型: Serum - 文献: Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression
样品类型: serum - 文献: A modified high-yield method for primary culture of rat retinal microglial cells
样品类型: microglial cell - 文献: Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats
样品类型: Brain tissue - 文献: Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF‐κB signalling to suppress osteoclastogenesis
样品类型: serum - 文献: Influence of lncRNA HOTAIR on acute kidney injury in sepsis rats through regulating miR-34a/Bcl-2 pathway.
样品类型: kidney tissues - 文献: Effect of Hydrogen on AM Pyroptosis Induced by Severe Burns in Rats
样品类型: lung tissues - 文献: Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator
样品类型: Serum - 文献: The modulatory effect of taurine on benzo (a) pyrene-induced hepatorenal toxicity
样品类型: serum - 文献: Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of Tamoxifen-treated rats
样品类型: hepatic,renal - 文献: High-Fat Diet Aggravates the Intestinal Barrier Injury via TLR4-RIP3 Pathway in a Rat Model of Severe Acute Pancreatitis
样品类型: serum - 文献: Exposure of aluminium to C6 glioma cells modulates molecular and functional neurotoxic markers
样品类型: C6 cell - 文献: Exploring the cardioprotective effects of canagliflozin against cisplatin-induced cardiotoxicity: Role of iNOS/NF-κB, Nrf2, and Bax/cytochrome C/Bcl-2 signals
样品类型: Cardiac - 文献: Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study
样品类型: blood - 文献: Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ
样品类型: sera - 文献: Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis
样品类型: serum - 文献: Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin
样品类型: hippocampal tissues - 文献: Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest
样品类型: Serum - 文献: Hydrogen Alleviates Neuronal Injury and Neuroinflammation Induced by Microglial Activation via the Nuclear Factor Erythroid 2-related Factor 2 Pathway in Sepsis-associated Encephalopathy
样品类型: Cell culture supernatant,Tissue homogenate(Brain) - 文献: NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis
样品类型: serum,muscle - 文献: Neuroprotective role of gallic acid in aflatoxin B1‐induced behavioral abnormalities in rats
样品类型: cerebrum tissue lysate supernatant - 文献: Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats
样品类型: Serum - 文献: IFI16 contributes to the pathogenesis of abdominal aortic aneurysm by regulating the caspase-1/IL-1β/MCPIP1 pathway
样品类型: Cell culture supernatant - 文献: Attenuation of chronic arsenic neurotoxicity via melatonin in male offspring of maternal rats exposed to arsenic during conception: Involvement of oxidative DNA damage and inflammatory signaling cascades
样品类型: Tissue homogenate - 文献: The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway
样品类型: heart tissue - 文献: Biochemical and histological alterations of doxorubicin-induced neurotoxicity in rats: Protective role of luteolin
样品类型: brain - 文献: Water extract of Armillaria mellea (Vahl) P. Kumm. Alleviates the depression-like behaviors in acute- and chronic mild stress-induced rodent models via anti-inflammatory action
样品类型: Serum,Tissue homogenate - 文献: Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways
样品类型: Serum - 文献: Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways
样品类型: Serum,Cell culture supernatant - 文献: Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133
样品类型: Cell culture supernatant - 文献: Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation
样品类型: serum - 文献: Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals
样品类型: kidney - 文献: Tenofovir-silver nanoparticles conjugate ameliorates neurocognitive disorders and protects ultrastructural and cytoarchitectonic properties of the prefrontal cortex in diabetic rats
样品类型: prefrontal cortex (PFC) - 文献: Vernonia amygdalina inhibited osteoarthritis development by anti‐inflammatory and anticollagenase pathways in cartilage explant and osteoarthritis‐induced rat model
样品类型: serum - 文献: In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway
样品类型: testicular - 文献: PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro
样品类型: Serum,Cell culture supernatant - 文献: Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway
样品类型: fibroblast-like synoviocytes (FLSs) - 文献: Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production
样品类型: Serum,Plasma,Cell sample - 文献: Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes
样品类型: hippocampus tissues - 文献: Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier
样品类型: brain - 文献: 8‐Br‐cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia–reperfusion injury
样品类型: Plasma - 文献: The method of Yiqi Yangyin Tongluo can attenuate the pyroptosis of rheumatoid arthritis chondrocytes through the ASIC1a/NLRP3 signaling pathway
样品类型: serum - 文献: Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats
样品类型: Plasma - 文献: Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis
样品类型: Serum - 文献: Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway
样品类型: H9c2 cell - 文献: Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis
样品类型: blood - 文献: The beneficial activity of curcumin and resveratrol loaded in nanoemulgel for healing of burn-induced wounds
样品类型: Tissue homogenate - 文献: The effects of exercise treatment on learning and memory ability, and cognitive performance in diet-induced prediabetes animals
样品类型: Tissue homogenate - 文献: Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats
样品类型: serum - 文献: miR-484 targeting of Yap1-induced LPS-inhibited proliferation, and promoted apoptosis and inflammation in cardiomyocyte
样品类型: Cell culture supernatant(H9c2 cells) - 文献: Sheng-Di-Da-Huang Decoction Inhibited Inflammation Expressed in Microglia after Intracerebral Hemorrhage in Rats
样品类型: brain tissues - 文献: Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood
样品类型: hippocampal tissue - 文献: Troxerutin attenuates oxygen‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes
样品类型: Cell culture supernatant - 文献: Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy
样品类型: Serum - 文献: Effect of retinoic acid on the function of lipopolysaccharide-stimulated bone marrow stromal cells grown on titanium surfaces
样品类型: Cell culture supernatant - 文献: Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats
样品类型: Tissue homogenate - 文献: Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate:
样品类型: hepatic and renal - 文献: Plant-derived oleanolic acid ameliorates markers of subclinical inflammation and innate immunity activation in diet-induced pre-diabetic rats:
样品类型: Plasma - 文献: Galangin Suppresses Renal Inflammation via the Inhibition of NF-κB, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells
样品类型: Cell culture supernatant - 文献: ASIC1a inhibits cell pyroptosis induced by acid‐induced activation of rat hepatic stellate cells
样品类型: Cell culture medium - 文献: The effects of phenanthrene exposure on Treg and Th17 cells related cytokines in female rats
样品类型: Tissue homogenate - 文献: Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity
样品类型: Serum - 文献: Investigation of the efficacy of daidzein in experimental knee osteoarthritis-induced with monosodium iodoacetate in rats
样品类型: Serum - 文献: Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats
样品类型: BALF - 文献: attenuates hydrogen peroxide induced oxidative toxicity in PC12 cells
样品类型: PC12 cells - 文献: Combination of quercetin and exercise training attenuates depression in rats with 1,2‐dimethylhydrazine‐induced colorectal cancer: Possible involvement of inflammation and BDNF signalling
样品类型: Serum,Tissue homogenate - 文献: Graphene oxide induces dose‑dependent lung injury in rats by regulating autophagy
样品类型: Tissue homogenate - 文献: Gadolinium chloride pre‑treatment reduces the inflammatory response and preserves intestinal barrier function in a rat model of sepsis
样品类型: serum,intestinal tissue - 文献: Emodin ameliorates acute pancreatitis‑induced lung injury by suppressing NLRP3 inflammasome‑mediated neutrophil recruitment
样品类型: serum - 文献: Activated protein C overexpression suppresses the pyroptosis of subarachnoid hemorrhage model cells by regulating the NLRP3 inflammasome pathway
样品类型: brain tissue - 文献: Maternal prenatal stress and depression-like behavior associated with hippocampal and cortical neuroinflammation in the offspring: An experimental study
样品类型: hippocampus - 文献: Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway
样品类型: Tissue homogenate - 文献: Healing Potential of Propolis Extract–Passiflora edulis Seed Oil Emulgel Against Excisional Wound: Biochemical, Histopathological, and Cytokines Level Evidence
样品类型: Skin samples - 文献: The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways
样品类型: H9c2 cell - 文献: Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
样品类型: brains - 文献: Cobalt exposure triggers impairments in cognitive and anxiety-like behaviors, brain oxidative stress and inflammation, and hippocampo-amygdala histomorphological alterations: Protective role of aqueous Prosopis africana seed extract
样品类型: Brain - 文献: Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors
样品类型: brain,neural stem cells - 文献: Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis
样品类型: Serum - 文献: Acid‐sensing ion channel 1a mediates acid‐induced pyroptosis through calpain‐2/calcineurin pathway in rat articular chondrocytes
样品类型: Cell culture supernatant - 文献: Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 signalling pathways in rats
样品类型: Lung tissue - 文献: Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance
样品类型: hepatic,renal - 文献: Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis
样品类型: renal - 文献: Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats
样品类型: Tissue homogenate - 文献: Si-Miao-Yong-An Decoction Maintains the Cardiac Function and Protects Cardiomyocytes from Myocardial Ischemia and Reperfusion Injury
样品类型: H9C2 cells - 文献: Moxibustion against Cyclophosphamide-Induced Premature Ovarian Failure in Rats through Inhibiting NLRP3-/Caspase-1-/GSDMD-Dependent Pyroptosis
样品类型: Serum - 文献: Cadmium and nickel co‐exposure exacerbates genotoxicity and not oxido‐inflammatory stress in liver and kidney of rats: Protective role of omega‐3 fatty acid
样品类型: Tissue homogenate - 文献: Justicia carnea extracts ameliorated hepatocellular damage in streptozotocin-induced type 1 diabetic male rats via decrease in oxidative stress, inflammation and increasing other risk markers
样品类型: liver - 文献: Evaluation of the therapeutic effects of calcium dobesilate in sciatic nerve crush injury in rats
样品类型: sciatic nerve - 文献: Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats:
样品类型: Tissue homogenate - 文献: Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains
样品类型: brain - 文献: Melatonin salvages lead-induced neuro-cognitive shutdown, anxiety, and depressive-like symptoms via oxido-inflammatory and cholinergic mechanisms
样品类型: brain - 文献: Effect of coconut water and milk on heat stress-induced gastrointestinal tract dysmotility in rats: Role of oxidative stress and inflammatory response
样品类型: stomach - 文献: Chlorogenic acid co-administration abates tamoxifen-mediated reproductive toxicities in male rats: An experimental approach
样品类型: Tissue homogenate - 文献: The protective role of neuregulin-1: A potential therapy for sepsis-induced cardiomyopathy
样品类型: Serum - 文献: Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model
样品类型: serum - 文献: Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model
样品类型: Serum - 文献: Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis
样品类型: Serum - 文献: S100A9‑containing serum exosomes obtained from patients with burn injuries promote myocardial cell pyroptosis through NLRP3
样品类型: AC16 cell - 文献: 1,2,3,4,6‑penta‑O‑galloyl‑β‑D‑glucose alleviates inflammation and oxidative stress in diabetic nephropathy rats through MAPK/NF‑κB and ERK/Nrf2/HO‑1 signaling pathways
样品类型: MPC5 cell - 文献: Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures
样品类型: Plasma - 文献: Agomelatine prevents indomethacin-induced gastric ulcer in rats
样品类型: gastric tissue - 文献: Achillea millefolium alleviates testicular damage in paclitaxel-intoxicated rats via attenuation of testicular oxido-inflammatory stress and apoptotic responses
样品类型: Tissue homogenate(testicular) - 文献: Hippocampal changes in inflammasomes, apoptosis, and MEMRI after radiation-induced brain injury in juvenile rats
样品类型: Tissue homogenate - 文献: The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy
样品类型: Plasma - 文献: Kukoamine B Ameliorate Insulin Resistance, Oxidative Stress, Inflammation and Other Metabolic Abnormalities in High-Fat/High-Fructose-Fed Rats
样品类型: serum - 文献: Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats
样品类型: Serum - 文献: Effects of depression on healing and inflammatory responses of acute wounds in rats
样品类型: serum - 文献: Nicotine lowers TNF-α, IL-1b secretion and leukocyte accumulation via nAChR in rat stomach
样品类型: Tissue homogenate - 文献: Nephroprotective effect of polyphenol-rich extract of Costus spicatus in cisplatin-induced nephrotoxicity in Wistar albino rats
样品类型: Kidney tissue - 文献: Rutin abrogates manganese—Induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway
样品类型: Tissue homogenate - 文献: Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats
样品类型: Tissue homogenate - 文献: Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis:
样品类型: Tissue homogenate - 文献: Carvacrol hinders the progression of hepatic fibrosis via targeting autotaxin and thioredoxin in thioacetamide-induced liver fibrosis in rat:
样品类型: liver - 文献: Biochemical assessment of the neurotoxicity of gold nanoparticles functionalized with colorectal cancer-targeting peptides in a rat model:
样品类型: Tissue homogenate(brain) - 文献: The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model
样品类型: Serum - 文献: Nobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressions
样品类型: Serum - 文献: NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease
样品类型: Cell - 文献: C5a aggravates dysfunction of the articular cartilage and synovial fluid in rats with knee joint immobilization
样品类型: Synovial fluid,Tissue homogenate - 文献: Exosomes derived from miR‐146a‐modified adipose‐derived stem cells attenuate acute myocardial infarction−induced myocardial damage via downregulation of early growth response factor 1
样品类型: Serum,Cell culture supernatant - 文献: Protective effect of betulinic acid on Freund's complete adjuvant‐induced arthritis in rats
样品类型: serum,synovium - 文献: Fluoride and diethylnitrosamine coexposure enhances oxido‐inflammatory responses and caspase‐3 activation in liver and kidney of adult rats
样品类型: Serum - 文献: Effect of phenylacetamide isolated from lepidium apetalum on myocardial injury in spontaneously hypertensive rats and its possible mechanism
样品类型: myocardial tissue - 文献: Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats
样品类型: Serum,Tissue homogenate - 文献: Melatonin ameliorates myocardial injury by reducing apoptosis and autophagy of cardiomyocytes in a rat cardiopulmonary bypass model
样品类型: Plasma - 文献: Fetal liver injury ameliorated by migration inhibitory factor inhibition in a rat model of acute pancreatitis in pregnancy
样品类型: serum - 文献: Examination of protective and therapeutic effects of ruscogenin on cerulein-induced experimental acute pancreatitis in rats
样品类型: Serum,Tissue homogenate - 文献: Anti-inflammatory Effects of a Small Molecule Gastrin-Releasing Peptide Receptor Antagonist on Adjuvant-Induced Rheumatoid Arthritis in rats
样品类型: serum - 文献: Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β
样品类型: Serum - 文献: Probiotic Saccharomyces boulardii Alleviates Lung Injury by Reduction of Oxidative Stress and Cytokine Response Induced by Supraceliac Aortic Ischemia-Reperfusion Injury in Rats
样品类型: serum,Lung tissue - 文献: Effects and mechanisms of cold atmospheric plasma on skin wound healing of rats
样品类型: skin tissues - 文献: Electroacupuncture reduces astrocyte number and oxidative stress in aged rats with surgery-induced cognitive dysfunction:
样品类型: Serum - 文献: Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti‐inflammatory, anti‐oxidative, and anti‐protease pathways
样品类型: Serum - 文献: Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity
样品类型: Tissue homogenate - 文献: Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats
样品类型: brain tissue,serum - 文献: miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4
样品类型: Cell culture supernatant - 文献: Vanillic Acid Alleviates Right Ventricular Function in Rats With MCT-Induced Pulmonary Arterial Hypertension
样品类型: serum - 文献: Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats
样品类型: Lung，kidney - 文献: Mucolytic and Antioxidant Effects of Intranasal Acetylcysteine Use on Acute Rhinosinusitis in Rats with an Acute Rhinosinusitis Model
样品类型: nose,sinuses - 文献: A preliminary study on fetal lung injury in a rat model of acute pancreatitis in pregnancy
样品类型: serum - 文献: Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism
样品类型: Serum - 文献: Effect of zinc supplementation on immunotoxicity induced by subchronic oral exposure to glyphosate-based herbicide (GOBARA®) in Wistar rats
样品类型: Serum - 文献: Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study
样品类型: Serum - 文献: Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress
样品类型: liver - 文献: The effects of chrysin on lipopolysaccharide‐induced sepsis in rats
样品类型: lung,liver,kidney - 文献: The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats
样品类型: Tissue homogenate - 文献: Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF in a rat model
样品类型: intervertebral discs - 文献: Nelumbo nucifera Gaertn. leaves: network pharmacology and molecular docking analysis of active ingredients and their mechanisms of action in treating atherosclerosis
样品类型: serum - 文献: Effects of Achillea millefolium on cisplatin induced ocular toxicity: an experimental study
样品类型: ocular - 文献: Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF–κB pathway and activation of Nrf2/ARE pathway in rats
样品类型: Serum,Urine,Tissue homogenate - 文献: MicroRNA‑22 alleviates inflammation in ischemic stroke via p38 MAPK pathways
样品类型: serum - 文献: Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats
样品类型: colonic tissue - 文献: Improvement in post-partum uterine involution in rats treated with Apios americana
样品类型: serum - 文献: Mechanism of TangGanJian on nonalcoholic fatty liver disease with type 2 diabetes mellitus
样品类型: serum - 文献: Carbon Monoxide Inhibits the Expression of Proteins Associated with Intestinal Mucosal Pyroptosis in a Rat Model of Sepsis Induced by Cecal Ligation and Puncture
样品类型: serum,intestinal tissue - 文献: Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats
样品类型: hippocampus - 文献: Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats
样品类型: Tissue homogenate - 文献: Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway
样品类型: cortical - 文献: Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos
样品类型: Tissue homogenate - 文献: Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines
样品类型: H4IIE cell,clone-9 cell - 文献: Highly active antiretroviral therapy-silver nanoparticle conjugate interacts with neuronal and glial cells and alleviates anxiety-like behaviour in streptozotocin-induced diabetic rats
样品类型: brain - 文献: Dose-related effects of dexmedetomidine on sepsis-initiated lung injury in rats
样品类型: plasma - 文献: Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the P38-MAPK/TXNIP signaling activation in streptozotocin induced diabetic rats
样品类型: Serum,Plasma - 文献: Protective effect of penehyclidine hydrochloride on lipopolysaccharide-induced acute kidney injury in rat.
样品类型: serum - 文献: Dopamine Pretreatment Protects Offspring Rats from LPS-Induced Hypertension and Kidney Damage by Inhibiting NLRP3 Activation in Kidney
样品类型: serum - 文献: Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats
样品类型: Serum - 文献: Mangiferin ameliorates intracerebroventricular-quinolinic acid-induced cognitive deficits, oxidative stress, and neuroinflammation in Wistar rats
样品类型: Tissue homogenate - 文献: Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.
样品类型: Serum
