Rat IL-6(Interleukin 6) ELISA Kit
大鼠白介素6(IL-6)酶联免疫吸附测定试剂盒
| 规格： | / 96T / 48T / 96T*5 |
| 价格： | / ￥2400 / ￥1650 / ￥10200 |
货号：E-EL-R0015
反应性: 大鼠
检测范围: 12.50~800 pg/mL
灵敏度: 7.50 pg/mL
用途
该试剂盒用于体外定量检测大鼠serum, plasma and other biological fluids中IL-6浓度
检测原理
本试剂盒采用双抗体夹心ELISA法。用抗大鼠IL-6抗体包被于酶标板上，实验时样品或标准品中的大鼠IL-6会与包被抗体结合，游离的成分被洗去。依次加入生物素化的抗大鼠IL-6抗体和辣根过氧化物酶标记的亲和素。抗大鼠IL-6抗体与结合在包被抗体上的大鼠IL-6结合、生物素与亲和素特异性结合而形成免疫复合物，游离的成分被洗去。加入显色底物(TMB)，TMB在辣根过氧化物酶的催化下呈现蓝色，加终止液后变成黄色。用酶标仪在450nm波长处测OD值，IL-6浓度与OD450值之间呈正比，通过绘制标准曲线计算出样品中IL-6的浓度。
| 反应类型 | 夹心法 |
| 规格 | 96T |
| 反应时间 | 3.5h |
| 反应性 | 大鼠 |
| 检测方法 | Colormetric |
| 检测范围 | 12.50—800 pg/mL |
| 灵敏度 | 7.50 pg/mL |
| 样本体积 | 100μL |
| 样本类型 | serum, plasma and other biological fluids |
特异性
可检测样本中的大鼠IL-6，且与其它相关蛋白无明显交叉反应。
重复性
板内，板间变异系数均<10%。
典型数据
由于实验操作条件的不同（如操作者、移液技术、洗板技术和稳定条件等），标准曲线的OD值会有所差异。以下数据和曲线仅供参考，实验者需根据自己的实验建立标准曲线。
| (pg/mL) | O.D | Average | Corrected |
|---|---|---|---|
| 800 | 2.567 2.418 |
2.493 | 2.435 |
| 400 | 1.7 1.628 |
1.664 | 1.606 |
| 200 | 0.982 0.971 |
0.977 | 0.919 |
| 100 | 0.478 0.512 |
0.495 | 0.437 |
| 50 | 0.278 0.271 |
0.275 | 0.217 |
| 25 | 0.181 0.184 |
0.183 | 0.125 |
| 12.50 | 0.12 0.121 |
0.121 | 0.063 |
| 0 | 0.056 0.059 |
0.058 | -- |
精密度
板内精密度:低浓度样本,中浓度样本和高浓度样本分别在1块板子上检测20次。
板间精密度:低浓度样本,中浓度样本和高浓度样本分别在3块板子上检测20次。
| Intra-assay Precision | Inter-assay Precision | |||||
|---|---|---|---|---|---|---|
| Sample | 1 | 2 | 3 | 1 | 2 | 3 |
| n | 20 | 20 | 20 | 20 | 20 | 20 |
| Mean (pg/mL) |
34.58 | 93.20 | 396.79 | 34.39 | 95.73 | 379.80 |
| Standard
deviation |
2.04 | 4.50 | 19.96 | 1.75 | 4.79 | 18.61 |
| C V (%) | 5.90 | 4.83 | 5.03 | 5.09 | 5.00 | 4.90 |
回收率
分别往5个不同样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围和平均回收率。
| Sample Type | Range (%) | Average Recovery (%) |
|---|---|---|
| Serum (n=5) | 98-111 | 105 |
| EDTA plasma (n=5) | 95-109 | 102 |
| Cell culture media (n=5) | 89-95 | 92 |
线性
分别往5个样本中添加已知浓度的目标蛋白，做回收实验，得出回收率范围及平均回收率。将5个样本分别稀释2倍，4倍，8倍，16倍做回收实验，得出回收率范围及平均回收率。
| Serum (n=5) | EDTA plasma (n=5) | Cell culture media (n=5) | ||
|---|---|---|---|---|
| 1:2 | Range (%) | 84-94 | 95-107 | 96-109 |
| Average (%) | 90 | 102 | 101 | |
| 1:4 | Range (%) | 93-102 | 99-108 | 88-99 |
| Average (%) | 96 | 103 | 92 | |
| 1:8 | Range (%) | 93-103 | 89-100 | 87-101 |
| Average (%) | 100 | 97 | 94 | |
| 1:16 | Range (%) | 86-96 | 101-108 | 83-93 |
| Average (%) | 90 | 105 | 90 |
试剂盒组成及保存
未拆封的试剂盒可在4℃保存一周；如果一周以后才使用试剂盒，请拆开试剂盒按照下表中的条件分别保存各组分。
| 中文名称 | 英文名称 | 规格 | 保存条件 |
|---|---|---|---|
| ELISA酶标板(可拆卸) | Micro ELISA Plate(Dismountable) | 8 孔×12 条 | -20℃，可存放6个月 |
| 冻干标准品 | Reference Standard | 2 支 | |
| 浓缩生物素化抗体(100×) | Concentrated Biotinylated Detection Ab | 1支 120 μL | |
| 浓缩HRP酶结合物(100×) | Concentrated HRP Conjugate | 1支 120 μL | -20℃(避光)，可存放6个月 |
| 标准品&样品稀释液 | Reference Standard & Sample Diluent | 1瓶 20 mL | 4℃.可存放6个月 |
| 生物素化抗体稀释液 | Biotinylated Detection Ab Diluent | 1瓶 14 mL | |
| 酶结合物稀释液 | HRP Conjugate Diluent | 1瓶 14 mL | |
| 浓缩洗涤液(25×) | Concentrated Wash Buffer (25×) | 1瓶 30 mL | |
| 底物溶液(TMB) | Substrate Reagent | 1瓶 10 mL | 4℃(避光) |
| 反应终止液 | Stop Solution | 1瓶 10 mL | 4℃ |
| 封板覆膜 | Plate Sealer | 5 张 | |
| 产品说明书 | Product Description | 1 份 | |
| 质检报告 | Certificate of Analysis | 1 份 |
说明：所有试剂瓶盖须旋紧以防止蒸发和微生物的污染。
试剂体积以实际发货版说明书为准。相关试剂在分装时会比标签上标明的体积稍多一些，请在使用时量取而非直接倒出。
试验所需自备物品
- 1. 酶标仪(450nm波长滤光片)
- 2. 高精度移液器，EP管及一次性吸头：0.5-10 μL, 2-20 μL, 20-200 μL, 200-1000 μL
- 3. 37℃恒温箱，双蒸水或去离子水
- 4. 吸水纸
操作步骤
|
|
1.对应板孔中加入100μL标准品工作液或样本，37℃孵育90分钟 |
| 2.弃掉板内液体后，立即加入100μL生物素化抗体工作液，37℃孵育60分钟 | |
| 3.弃掉板内液体，洗板3次 | |
| 4.每孔加入100μL HRP酶结合物工作液，37℃孵育30分钟，弃掉板内液体，洗板5次 | |
| 5.每孔加入90μL底物溶液，37℃孵育15分钟 | |
| 6.每孔加入50μL终止液 | |
| 7.立即在450nm波长下读数，处理数据 |
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样品类型: serum - 文献: PLGA/PCADK composite microspheres containing hyaluronic acid–chitosan siRNA nanoparticles: A rational design for rheumatoid arthritis therapy
样品类型: Serum - 文献: Hepatoprotective effect of acetovanillone against methotrexate hepatotoxicity: Role of Keap-1/Nrf2/ARE, IL6/STAT-3, and NF-κB/AP-1 signaling pathways
样品类型: liver - 文献: Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats
样品类型: serum - 文献: Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.
样品类型: hepatic tissue - 文献: Anti-arthritic and toxicological evaluation of ethanolic extract of Alternanthera bettzickiana in rats.
样品类型: serum - 文献: Evaluation of testicular torsion management in Ogbomoso, South-Western Nigeria and surgical detorsion-augmented treatment with phytochemical fractions of Corchorus olitorius leaf in experimental rats
样品类型: testicular tissue - 文献: Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats
样品类型: serum - 文献: Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress
样品类型: Serum,Bronchoalveolar Lavage Fluid,Tissue homogenate - 文献: Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats
样品类型: Serum - 文献: the NF-κB Pathway in Rats
样品类型: Plasma - 文献: Neuropeptide W Attenuates Oxidative Multi-Organ Injury in Rats Induced with Intra-Abdominal Sepsis
样品类型: serum - 文献: MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression
样品类型: Tissue homogenate,Cell culture supernatant - 文献: MeCP2 Regulates PTCH1 Expression Through DNA Methylation in Rheumatoid Arthritis
样品类型: Cell culture supernatant - 文献: hUC-MSCs exosomal miR-451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF-PI3K-AKT signaling pathway
样品类型: serum,NR8383 cell - 文献: LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway
样品类型: bronchoalveolar lavage fluid (BALF) - 文献: Iron-induced cellular in vitro neurotoxic responses in rat C6 cell line
样品类型: glioma C6 cell - 文献: Imbalanced inflammatory response in subchronic arsenic-induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cell interactions
样品类型: serum,liver - 文献: Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats
样品类型: serum - 文献: 2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide
样品类型: serum - 文献: Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds
样品类型: serum - 文献: Comparative Biochemical Profiling of Aluminum Chloride and Sodium Azide Induced Neuroinflammation and Cardiometabolic Disturbance
样品类型: serum - 文献: Ajuga bracteosa Exerts Antihypertensive Activity in l-NAME-Induced Hypertension Possibly through Modulation of Oxidative Stress, Proinflammatory Cytokines, and the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway
样品类型: serum - 文献: Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dementia
样品类型: brain lysate supernatant - 文献: Post-weaning Social Isolated Flinders Sensitive Line Rats Display Bio-Behavioural Manifestations Resistant to Fluoxetine: A Model of Treatment-Resistant Depression
样品类型: plasma - 文献: MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2
样品类型: serum - 文献: Sodium Tanshinone II Sulfonate A Ameliorates Hypoxia-Induced Pulmonary Hypertension
样品类型: Tissue homogenate - 文献: Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability
样品类型: Bronchoalveolar Lavage Fluid - 文献: Pharmacological Effects of Methotrexate and Infliximab in a Rats Model of Diet-Induced Dyslipidemia and Beta-3 Overexpression on Endothelial Cells
样品类型: plasma - 文献: Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF- κ B signaling pathways
样品类型: Tissue homogenate - 文献: Effect of Qianghuo Erhuang Decoction on T Regulatory and T Helper 17 Cells in Treatment of Adjuvant-induced Arthritis in Rats
样品类型: Serum - 文献: Sodium para-aminosalicylic acid ameliorates brain neuroinflammation and behavioral deficits in juvenile lead-exposed rats by modulating MAPK signaling pathway and alpha-synuclein
- 文献: Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis
样品类型: Serum - 文献: Inflammation-dependent ISG15 upregulation mediates MIA-induced dendrite damages and depression by disrupting NEDD4/Rap2A signaling
样品类型: Serum - 文献: Ziziphus Oxyphylla hydro-methanolic extract ameliorates hypertension in L-NAME induced hypertensive rats through NO/cGMP pathway and suppression of oxidative stress related inflammatory biomarkers.
样品类型: Serum - 文献: Arjunolic acid from Cyclocarya paliurus ameliorates diabetic retinopathy through AMPK/mTOR/HO-1 regulated autophagy pathway
样品类型: retinal tissue - 文献: Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways
样品类型: serum - 文献: Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier
样品类型: Tissue homogenate - 文献: BMSC-EVs overexpressing PD-L1 ameliorate DSS-induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis
样品类型: blood,colon - 文献: Protective effect of ethanolic extract of Echinacea purpurea contained nanoparticles on meniscal/ligamentous injury induced osteoarthritis in obese male rats
样品类型: plasma - 文献: Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring
样品类型: serum - 文献: Low-intensity low-frequency pulsed ultrasound ameliorates sciatic nerve dysfunction in a rat model of cisplatin-induced peripheral neuropathy
样品类型: serum - 文献: Chondroitin and glucosamine sulphate reduced proinflammatory molecules in the DRG and improved axonal function of injured sciatic nerve of rats
样品类型: dorsal root ganglia - 文献: Acetate rescues defective brain-adipose metabolic network in obese Wistar rats by modulation of peroxisome proliferator-activated receptor-γ
样品类型: plasma,brain tissue,adipose tissue - 文献: Accelerated Blood Clearance of Nanoemulsions Modified with PEG-Cholesterol and PEG-Phospholipid Derivatives in Rats: The Effect of PEG-Lipid Linkages and PEG Molecular Weights
样品类型: Serum - 文献: NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis
样品类型: Tissue homogenate,Cell lysate,Serum - 文献: Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways
样品类型: serum - 文献: Suppression of glutathione system and upregulation of caspase 3-dependent apoptosis mediate rohypnol-induced gastric injury
样品类型: gastric tissue - 文献: Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair
样品类型: serum,white matter samples - 文献: Synthesis and Biological Evaluation of Benzimidazole Derivatives as Potential Neuroprotective Agents in an Ethanol-Induced Rodent Model
样品类型: Tissue homogenate(Brain) - 文献: Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4
样品类型: serum - 文献: Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-κB signalling pathway
样品类型: serum,sciatic nerves - 文献: PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis
样品类型: serum - 文献: Piperazine ferulate protects against cardiac ischemia/reperfusion injury in rat via the suppression of NLRP3 inflammasome activation and pyroptosis
样品类型: serum - 文献: Glycyrrhizic acid ameliorates myocardial ischemia-reperfusion injury in rats through inhibiting endoplasmic reticulum stress
样品类型: serum - 文献: Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model
样品类型: Serum - 文献: Bisindole compound 4ae ameliorated cognitive impairment in rats with vascular dementia by anti-inflammation effect via microglia cells
样品类型: BV2 cells - 文献: CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits
样品类型: Tissue homogenate,Cell culture medium - 文献: Sarcococca saligna extract attenuates formaldehyde-induced arthritis in Wistar rats via modulation of pro-inflammatory and inflammatory biomarkers
样品类型: blood - 文献: Exploring the role of Aquaporins (AQPs) in LPS induced systemic inflammation and the ameliorative effect of Garcinia in male Wistar rat
样品类型: serum - 文献: Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis
样品类型: Plasma - 文献: Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5
样品类型: Serum - 文献: C1q/TNF‐related protein‐9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction
样品类型: Tissue homogenate - 文献: Selenium abates manganese–induced striatal and hippocampal toxicity via abrogation of neurobehavioral deficits, biometal accumulation, oxidative stress, inflammation, and caspase-3 activation in rats
样品类型: striatum,hippocampus - 文献: Semen Brassicae reduces thoracic aortic remodeling, inflammation, and oxidative damage in spontaneously hypertensive rats
样品类型: Serum - 文献: Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota
样品类型: Tissue homogenate - 文献: 6-gingerol ameliorates weight gain and insulin resistance in metabolic syndrome rats by regulating adipocytokines
样品类型: serum,liver,adipose tissue - 文献: Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats
样品类型: serum - 文献: Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and anti-angiogenic effects in an experimental rat model
样品类型: Serum,intraperitoneal fluid - 文献: Zinc and selenium mitigated heavy metals mixture (Pb, Al, Hg and Mn) mediated hepatic-nephropathy via modulation of oxido-inflammatory status and NF‑kB signaling in female albino rats
样品类型: liver,kidney - 文献: Expression and Role of the Calcium-Sensing Receptor in Rat Peripheral Blood Polymorphonuclear Neutrophils
样品类型: Cell culture supernatant - 文献: Study of double-targeting nanoparticles loaded with MCL-1 siRNA and dexamethasone for adjuvant-induced arthritis therapy
样品类型: Serum - 文献: Hyperbaric Oxygen Intervention Modulates Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats: Possible Involvement of TLR4/NF-κ B-Mediated Signaling Pathway
样品类型: Tissue homogenate - 文献: Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury
样品类型: lung tissue - 文献: Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study
样品类型: knee articular tissue - 文献: The Effect of Extraction Methods on Phytochemicals and Biological Activities of Green Coffee Beans Extracts
样品类型: plantar tissue - 文献: Influences of Different Extraction Techniques and Their Respective Parameters on the Phytochemical Profile and Biological Activities of Xanthium spinosum L. Extracts
样品类型: plantar tissue - 文献: Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain
样品类型: Plasma - 文献: Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis
样品类型: Serum - 文献: Effects of different simulated submarine escape depths by free ascent in animal models
样品类型: Serum - 文献: Kinetin Ameliorates Cisplatin-Induced Hepatotoxicity and Lymphotoxicity via Attenuating Oxidative Damage, Cell Apoptosis and Inflammation in Rats
样品类型: lymphocytes - 文献: Effect of Celecoxib and Infliximab against Multiple Organ Damage Induced by Sepsis in Rats: A Comparative Study
样品类型: Serum - 文献: Anti-inflammatory effect of epidermal growth factor conjugated silk fibroin immobilized polyurethane ameliorates diabetic burn wound healing
样品类型: Serum,Tissue homogenate - 文献: Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPK/Nrf-2/HO-1/NF-κB In Vitro and In Vivo
样品类型: serum,LV(left ventricular) myocardium,H9c2 cells - 文献: Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: The regulation of autophagy and ROS production
样品类型: Serum - 文献: Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury
样品类型: intestinal,hepatic - 文献: Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects
样品类型: brain - 文献: 7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation
样品类型: serum - 文献: Serum Metabolomics Based on GC-MS Reveals the Antipyretic Mechanism of Ellagic Acid in a Rat Model
样品类型: serum - 文献: MAST3 modulates the inflammatory response and proliferation of fibroblast-like synoviocytes in rheumatoid arthritis
样品类型: FLSs cells - 文献: Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway
样品类型: brain - 文献: Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways
样品类型: Cells - 文献: Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro
样品类型: Cell culture supernatant,Tissue homogenate - 文献: TGR5 receptor activation attenuates diabetic retinopathy through suppression of RhoA/ROCK signaling
样品类型: retinas - 文献: Gallic acid abates cadmium chloride toxicity via alteration of neurotransmitters and modulation of inflammatory markers in Wistar rats
样品类型: brain - 文献: Curative effect and mechanisms of Radix Arnebiae oil on burn wound healing in rats
样品类型: burn wound tissue - 文献: Ulinastatin reduces myocardial injury induced by doxorubicin in SD rats.
样品类型: Serum - 文献: The effect of myocardial infarction-associated transcript 2 (Mirt2) and miR-101 on sepsis-induced myocardial injury in rats.
样品类型: Serum - 文献: The novel estrogen receptor GPER1 decreases epilepsy severity and susceptivity in the hippocampus after status epilepticus
样品类型: Hippocampus - 文献: EFFECT OF INTRAPERITONEAL RESUSCITATION WITH DIFFERENT CONCENTRATIONS OF SODIUM PYRUVATE ON INTESTINAL ISCHEMIA REPERFUSION INJURY IN HEMORRHAGIC SHOCK RAT
样品类型: intestinal tissue - 文献: DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway
样品类型: Hippocampal tissue - 文献: Venenum Bufonis induces rat neuroinflammation by activiating NF-κB pathway and attenuation of BDNF
样品类型: Tissue homogenate - 文献: Platelet-rich plasma and/or sildenafil topical applications accelerate and better repair wound healing in rats through regulation of proinflammatory cytokines and collagen/TGF-β1 pathway
样品类型: Serum - 文献: Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors
样品类型: Plasma,Tissue homogenate - 文献: Effects of combination of obesity, diabetes, and hypoxia on inflammatory regulating genes and cytokines in rat pancreatic tissues and serum
样品类型: serum - 文献: Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines
样品类型: Serum - 文献: Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen‐Induced Arthritis
样品类型: Cell culture supernatant - 文献: Holistic and dynamic metabolic alterations of traditional Chinese medicine syndrome in a toxic heat and blood stasis syndrome rat model
样品类型: plasma - 文献: H2S attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty:
样品类型: Plasma - 文献: Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries
样品类型: serum - 文献: STING mediates SU5416/hypoxia-induced pulmonary arterial hypertension in rats by regulating macrophage NLRP3 inflammasome activation
样品类型: lung tissues,Bone marrow-derived macrophage (BMDMs) - 文献: Therapeutic effect of treatment with metformin and/or 4-hydroxychalcone in male Wistar rats with nonalcoholic fatty liver disease
样品类型: serum - 文献: Associations of inflammatory markers and vascular cell adhesion molecule-1 with endothelial dysfunction in collagen-induced arthritis
样品类型: Serum - 文献: Small Molecule Inhibiting Nuclear Factor‐kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan‐Induced Diabetic Nephropathy in Rat
样品类型: Tissue homogenate - 文献: Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation
样品类型: serum - 文献: KGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats
样品类型: intestinal tissue - 文献: Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke
样品类型: Tissue homogenate - 文献: The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways
样品类型: Bronchoalveolar Lavage Fluid,Serum,Tissue homogenate - 文献: The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis
样品类型: serum - 文献: Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model
样品类型: Plasma,liver tissue,adipose tissue - 文献: Thromboxane A2 synthase inhibition ameliorates endothelial dysfunction, memory deficits, oxidative stress and neuroinflammation in rat model of streptozotocin diabetes induced dementia
样品类型: brain - 文献: Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation
样品类型: heart tissue - 文献: Ferulic Acid Treats Gastric Ulcer via Suppressing Oxidative Stress and Inflammation
样品类型: gastric tissue - 文献: Celastrol mitigates high glucose‐induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR‐345‐5p/growth arrest‐specific 6
样品类型: H9c2 cell - 文献: Low-dose spironolactone ameliorates adipose tissue inflammation and apoptosis in letrozole-induced PCOS rat model
样品类型: adipose tissue - 文献: Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation
样品类型: Tissue homogenate(Hippocampal tissues) - 文献: Protective effects of Ulinastatin on oxidative stress and inflammation of rat-derived cardiomyocytes H9c2
样品类型: H9c2 cells - 文献: Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-induced Osteopenia and Steatosis in Rats
样品类型: serum - 文献: DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis
样品类型: synovial fluid - 文献: Dehydroevodiamine Suppresses Inflammatory Responses in Adjuvant-Induced Arthritis Rats and Human Fibroblast-Like Synoviocytes
样品类型: serum - 文献: Protective effect of Ganoderic acid A on adjuvant-induced arthritis
样品类型: Serum - 文献: Metformin attenuates sepsis-induced neuronal injury and cognitive impairment
样品类型: hippocampus tissue - 文献: Octreotide alleviates pancreatic damage caused by paraquat in rats by reducing inflammatory responses and oxidative stress
样品类型: Serum,Tissue homogenate - 文献: Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance
样品类型: Serum - 文献: Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways
样品类型: Serum - 文献: SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy
样品类型: Tissue homogenate - 文献: ) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study
样品类型: serum - 文献: Cardioprotective effects of a ruthenium (II) Schiff base complex in diet-induced prediabetic rats
样品类型: Tissue homogenate,Plasma - 文献: Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis
样品类型: Serum,amygdala - 文献: Modulation of nociception and pain-evoked neurobehavioral responses by levetiracetam in a craniotomy pain model
样品类型: serum - 文献: Wound Healing Activity of the Flavonoid-Enriched Fraction of Selaginella bryopteris Linn. against Streptozocin-Induced Diabetes in Rats
样品类型: skin - 文献: Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS
样品类型: Plasma - 文献: Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an experimental model of non-alcoholic steatohepatitis in rats
样品类型: Serum - 文献: The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats
样品类型: lung tissue - 文献: Rupatadine protects the intestinal mucosa from injury by 5-flurouracil via modulation of inflammation, apoptosis and intestinal permeability
样品类型: intestinal - 文献: The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats
样品类型: Tissue homogenate - 文献: Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis
样品类型: Serum - 文献: TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid
样品类型: serum,adipocytes - 文献: Effect of Clostridium butyricum and Butyrate on Intestinal Barrier Functions: Study of a Rat Model of Severe Acute Pancreatitis With Intra-Abdominal Hypertension
样品类型: Plasma - 文献: Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response
样品类型: Tissue homogenate - 文献: iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin–angiotensin system-mediated congenital ureteropelvic junction obstruction
样品类型: Serum,Cell sample - 文献: Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor
样品类型: Tissue homogenate( liver) - 文献: Celastrol Attenuates Learning and Memory Deficits in an Alzheimer’s Disease Rat Model
样品类型: brain - 文献: Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate metabolizing enzymes
样品类型: serum - 文献: The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats
样品类型: serum - 文献: Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes
样品类型: Serum - 文献: Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study
样品类型: Tissue homogenate - 文献: Comparison of the Protective Effect of Different Mild Therapeutic Hypothermia Temperatures on Intestinal Injury After Cardiopulmonary Resuscitation in Rats
样品类型: plasma,intestinal tissue - 文献: Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity
样品类型: Serum - 文献: Synergistic and non-synergistic effects of salmon calcitonin and omega - 3 fatty acids on antioxidant, anti-inflammatory, and haematological indices in diabetic rats
样品类型: plasma - 文献: A modified high-yield method for primary culture of rat retinal microglial cells
样品类型: microglial cell - 文献: Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats
样品类型: Brain tissue - 文献: Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet
样品类型: plasma - 文献: Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF‐κB signalling to suppress osteoclastogenesis
样品类型: serum - 文献: Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway
样品类型: serum - 文献: Renal ischemia-reperfusion injury attenuated by splenic ischemic preconditioning.
样品类型: serum - 文献: Pilocarpine improves submandibular gland dysfunction in irradiated rats by downregulating the tight junction protein claudin-4
样品类型: glands - 文献: Sarcococca saligna Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund’s Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers
样品类型: serum - 文献: Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS)
样品类型: Cell culture supernatant - 文献: Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator
样品类型: Serum - 文献: High-Fat Diet Aggravates the Intestinal Barrier Injury via TLR4-RIP3 Pathway in a Rat Model of Severe Acute Pancreatitis
样品类型: serum - 文献: Exposure of aluminium to C6 glioma cells modulates molecular and functional neurotoxic markers
样品类型: C6 cell - 文献: Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study
样品类型: blood - 文献: Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ
样品类型: sera - 文献: Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis
样品类型: serum - 文献: Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin
样品类型: hippocampal tissues - 文献: Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest
样品类型: Serum - 文献: Epigallocatechin gallate attenuates mitochondrial DNA-induced inflammatory damage in the development of ventilator-induced lung injury
样品类型: Tissue homogenate - 文献: Acetate-mediated-obestatin modulation attenuates adipose-hepatic dysmetabolism in high fat diet-induced obese rat model
样品类型: plasma,adipose,hepatic - 文献: Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats
样品类型: Serum - 文献: IFI16 contributes to the pathogenesis of abdominal aortic aneurysm by regulating the caspase-1/IL-1β/MCPIP1 pathway
样品类型: Cell culture supernatant - 文献: Curcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathway.
样品类型: Serum - 文献: Attenuation of chronic arsenic neurotoxicity via melatonin in male offspring of maternal rats exposed to arsenic during conception: Involvement of oxidative DNA damage and inflammatory signaling cascades
样品类型: Tissue homogenate - 文献: The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway
样品类型: heart tissue - 文献: Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis
样品类型: gastric tissue - 文献: Renoprotective effect of vinpocetine against ischemia/reperfusion injury: Modulation of NADPH oxidase/Nrf2, IKKβ/NF-κB p65, and cleaved caspase-3 expressions
样品类型: Renal - 文献: Anti-inflammatory potential of berberine-rich extract via modulation of inflammation biomarkers
样品类型: serum - 文献: Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase‑1/IL‑1β Signaling Pathway Inhibition
样品类型: Cell culture supernatant - 文献: Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
样品类型: plasma - 文献: Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133
样品类型: Cell culture supernatant - 文献: Combination Antiretroviral Therapy (cART) in Diabetes Exacerbates Diabetogenic Effects on Hippocampal Microstructure, Neurogenesis and Cytokine Perturbation in Male Sprague Dawley Rats
样品类型: brain - 文献: Essential Trace Elements Prevent the Impairment in the Retention Memory, Cerebral Cortex, and Cerebellum Damage in Male Rats Exposed to Quaternary Metal Mixture by Up-regulation, of Heme Oxygynase-1 and Down-regulation of Nuclear Factor Erythroid 2-related Factor 2-NOs Signaling Pathways
样品类型: cerebral cortex,cerebellum - 文献: Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals
样品类型: kidney - 文献: HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury
样品类型: serum,Human Umbilical Vein Endothelial Cells (HUVECs) - 文献: Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage
样品类型: brain - 文献: Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model
样品类型: plasma - 文献: Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway
样品类型: Soil,Water,Oil,Plant Tissue,Plant Fluid,Antibody,Fluoro - 文献: Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats
样品类型: blood,caecum - 文献: Synthesis and characterization of barium-doped bioactive glass with potential anti-inflammatory activity
样品类型: Cell culture supernatant - 文献: PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro
样品类型: Serum,Cell culture supernatant - 文献: Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes
样品类型: hippocampus tissues - 文献: Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier
样品类型: brain - 文献: Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway
样品类型: Ovary - 文献: MMP2/9 downregulation is responsible for hepatic function recovery in cirrhotic rats following associating liver partition and portal vein ligation for staged hepatectomy
样品类型: serum - 文献: Conjugated linoleic acid prompts bone formation in ovariectomized osteoporotic rats and weakens osteoclast formation after treatment with ultraviolet B
样品类型: Serum - 文献: Senomorphic agent pterostilbene ameliorates osteoarthritis through the PI3K/AKT/NF-κB axis: an in vitro and in vivo study.
样品类型: knee intra-articular lavage fluid - 文献: The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats
样品类型: Plasma - 文献: Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats
样品类型: Plasma - 文献: Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis
样品类型: Serum - 文献: Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway
样品类型: H9c2 cell - 文献: Brain-derived extracellular vesicles mediated coagulopathy, inflammation and apoptosis after sepsis
样品类型: blood - 文献: Liraglutide Lowers Body Weight Set Point in DIO Rats and its Relationship with Hypothalamic Microglia Activation
样品类型: Cell culture supernatant - 文献: Cold stress provokes lung injury in rats co-exposed to fine particulate matter and lipopolysaccharide
样品类型: Tissue homogenate - 文献: Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells
样品类型: primary astrocyte cell - 文献: Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo
样品类型: Tissue homogenate - 文献: Edible Bird’s Nest attenuates high fat diet-induced oxidative stress and inflammation via regulation of hepatic antioxidant and inflammatory genes
样品类型: Serum - 文献: The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer
样品类型: serum - 文献: miR-484 targeting of Yap1-induced LPS-inhibited proliferation, and promoted apoptosis and inflammation in cardiomyocyte
样品类型: Cell culture supernatant(H9c2 cells) - 文献: Protective effect of oleuropein on ketamine-induced cardiotoxicity in rats
样品类型: Serum - 文献: Electroacupuncture restores intestinal mucosal barrier through TLR4/NF-κB p65 pathway in functional dyspepsia-like rats
样品类型: Blood - 文献: Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood
样品类型: hippocampal tissue - 文献: Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy
样品类型: Serum - 文献: A. Chev root extracts against induced testicular inflammation and impaired spermatogenesis in adult rats
样品类型: Serum,Tissue homogenate - 文献: Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain
样品类型: Tissue homogenate - 文献: Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats
样品类型: Tissue homogenate - 文献: Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats
样品类型: serum - 文献: MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway
样品类型: serum - 文献: Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization
样品类型: HAPI cell - 文献: Histopathological and biochemical changes in the development of nonalcoholic fatty liver disease induced by high-sucrose diet at different times
样品类型: Serum - 文献: Effect of Pramipexole on Inflammatory Response in Central Nervous System of Parkinson's Disease Rat Model
样品类型: brain - 文献: Mild Hypothermia Therapy Lowers the Inflammatory Level and Apoptosis Rate of Myocardial Cells of Rats with Myocardial Ischemia-Reperfusion Injury via the NLRP3 Inflammasome Pathway
样品类型: H9c2 cell - 文献: SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22
样品类型: Tissue homogenate - 文献: Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats
样品类型: serum - 文献: The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model
样品类型: Plasma - 文献: Chitosan-Coated Solid Lipid Nano-Encapsulation Improves the Therapeutic Antiairway Inflammation Effect of Berberine against COPD in Cigarette Smoke-Exposed Rats
样品类型: BALF - 文献: attenuates hydrogen peroxide induced oxidative toxicity in PC12 cells
样品类型: PC12 cells - 文献: H2S attenuates sepsis‑induced cardiac dysfunction via a PI3K/Akt‑dependent mechanism
样品类型: serum - 文献: Graphene oxide induces dose‑dependent lung injury in rats by regulating autophagy
样品类型: Tissue homogenate - 文献: Gadolinium chloride pre‑treatment reduces the inflammatory response and preserves intestinal barrier function in a rat model of sepsis
样品类型: serum,intestinal tissue - 文献: Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats
样品类型: Serum,Tissue homogenate - 文献: Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway
样品类型: Tissue homogenate - 文献: Edaravone attenuates lipopolysaccharide-induced acute respiratory distress syndrome associated early pulmonary fibrosis via amelioration of oxidative stress and transforming growth factor-β1/Smad3 signaling
样品类型: Serum - 文献: Contraceptive potential of Andrographis paniculata is via androgen suppression and not induction of oxidative stress in male Wistar rats
样品类型: testicular - 文献: Abnormal expression of HSP70 may contribute to PCOS pathology
样品类型: serum - 文献: Healing Potential of Propolis Extract–Passiflora edulis Seed Oil Emulgel Against Excisional Wound: Biochemical, Histopathological, and Cytokines Level Evidence
样品类型: Skin samples - 文献: Dexamethasone and potassium canrenoate alleviate hyperalgesia by competitively regulating IL-6/JAK2/STAT3 signaling pathway during inflammatory pain in vivo and in vitro
样品类型: spinal cord - 文献: The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways
样品类型: H9c2 cell - 文献: MicroRNA-24 regulates vascular remodeling via inhibiting PDGF-BB pathway in diabetic rat model
样品类型: Tissue homogenate - 文献: Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors
样品类型: brain,neural stem cells - 文献: Shenqi Fuzheng Injection impairs bile duct ligation-induced cholestatic liver injury in vivo
样品类型: Tissue homogenate - 文献: Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers
样品类型: Plasma,Tissue homogenate - 文献: Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 signalling pathways in rats
样品类型: Lung tissue - 文献: Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis
样品类型: Plasma - 文献: Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats
样品类型: Tissue homogenate - 文献: Dose Dependent Effects of Breynia cernua Against the Paraquat Induced Parkinsonism like Symptoms in Animals’ Model: In Vitro, In Vivo and Mechanistic Studies
样品类型: brain tissue - 文献: Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion :
样品类型: serum,Pancreatic,intestinal tissue - 文献: Molecular Mechanism of Traditional Chinese Ointment of Xuzhou Qufu Shengji in Infected Wounds
样品类型: skin - 文献: Etlingera elatior Flower Aqueous Extract Protects against Oxidative Stress-Induced Nephropathy in a Rat Model of Type 2 Diabetes
样品类型: kidney tissue - 文献: Orthosiphon stamineus (Misai Kucing) ameliorated postmenopausal osteoporosis in rat model
样品类型: serum - 文献: Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats:
样品类型: Tissue homogenate - 文献: Salvinorin A inhibits ovalbumin-stimulated allergic rhinitis and RBL-2H3 cells degranulation
样品类型: RBL-2H5 cells - 文献: Molecular mechanisms underlying ameliorative impact of melatonin against age-dependent chronic arsenic toxicity in rats' brains
样品类型: brain - 文献: Effects and mechanisms of Geniposide on rats with adjuvant arthritis
样品类型: Cell lysate - 文献: Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis
样品类型: Cell culture supernatant - 文献: Effect of coconut water and milk on heat stress-induced gastrointestinal tract dysmotility in rats: Role of oxidative stress and inflammatory response
样品类型: stomach - 文献: The protective role of neuregulin-1: A potential therapy for sepsis-induced cardiomyopathy
样品类型: Serum - 文献: Folate receptor-β targeted cholesterol-chitosan nanocarrier for treatment of rheumatoid arthritis: An animal study
样品类型: serum - 文献: Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis
样品类型: Serum - 文献: Angiotensin aldosterone inhibitors improve survival and ameliorate kidney injury induced by sepsis through suppression of inflammation and apoptosis
样品类型: serum - 文献: Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures
样品类型: Plasma - 文献: Ameliorative effect of Ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia‐induced experimental vascular cognitive impairment and dementia
样品类型: Tissue homogenate - 文献: Agomelatine prevents indomethacin-induced gastric ulcer in rats
样品类型: gastric tissue - 文献: Anti-steatotic and anti-inflammatory effects of Hovenia dulcis Thunb. extracts in chronic alcohol-fed rats
样品类型: Serum - 文献: High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats
样品类型: Serum - 文献: Cysteamine mitigates torsion/detorsion-induced reperfusion injury via inhibition of apoptosis, oxidative stress and inflammatory responses in experimental rat model
样品类型: serum - 文献: Diabetes escalates knee osteoarthritis in rats: Evidence of adaptive mechanism
样品类型: Serum - 文献: MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1
样品类型: serum - 文献: Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats
样品类型: Tissue homogenate - 文献: Zingerone Administered Neonatally Prevents the Subsequent Development of High Dietary Fructose-Induced Fatty Liver in Sprague Dawley Rats
样品类型: plasma - 文献: Inhibition of the fatty acid amide hydrolase changes behaviors and brain catecholamines in a sex-specific manner in rats exposed to chronic unpredictable stress
样品类型: Tissue homogenate - 文献: The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy
样品类型: Plasma - 文献: The comparison of changes in fecal and mucosal microbiome in metabolic endotoxemia induced by a high-fat diet
样品类型: serum,colon - 文献: Kukoamine B Ameliorate Insulin Resistance, Oxidative Stress, Inflammation and Other Metabolic Abnormalities in High-Fat/High-Fructose-Fed Rats
样品类型: serum - 文献: Activation of Nrf2 Signaling by Apelin Attenuates Renal Ischemia Reperfusion Injury in Diabetic Rats
样品类型: Serum - 文献: Studies on Haloperidol and Adjunctive α-Mangostin or Raw Garcinia mangostana Linn Pericarp on Bio-Behavioral Markers in an Immune-Inflammatory Model of Schizophrenia in Male Rats
样品类型: plasma - 文献: Effects of depression on healing and inflammatory responses of acute wounds in rats
样品类型: serum - 文献: Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies
样品类型: Serum - 文献: Nephroprotective effect of polyphenol-rich extract of Costus spicatus in cisplatin-induced nephrotoxicity in Wistar albino rats
样品类型: Kidney tissue - 文献: Rutin abrogates manganese—Induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway
样品类型: Tissue homogenate - 文献: Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats
样品类型: Tissue homogenate - 文献: Phenolics-Enriched Fraction of Pterospermum Lanceifolium Roxb. efficiently Reverses the Hepatocellular Carcinoma in NDEA-Induced HCC Rats
样品类型: Tissue homogenate - 文献: Biochemical assessment of the neurotoxicity of gold nanoparticles functionalized with colorectal cancer-targeting peptides in a rat model:
样品类型: Tissue homogenate(brain) - 文献: The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model
样品类型: Serum - 文献: Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats
样品类型: serum - 文献: Apocynin Attenuates Acute Kidney Injury and Inflammation in Rats with Acute Hypertriglyceridemic Pancreatitis
样品类型: Serum - 文献: Protective Effects of Tyrosol Against DSS-Induced Ulcerative Colitis in Rats
样品类型: colon tissue - 文献: Nobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressions
样品类型: Serum - 文献: Puerarin reduces ischemia/reperfusion-induced myocardial injury in diabetic rats via upregulation of vascular endothelial growth factor A/angiotensin-1 and suppression of apoptosis
样品类型: plasma - 文献: NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease
样品类型: Cell - 文献: MAPKs and NF‐κB‐mediated acrylamide‐induced neuropathy in rat striatum and human neuroblastoma cells SY5Y
样品类型: Tissue homogenate - 文献: Exosomes derived from miR‐146a‐modified adipose‐derived stem cells attenuate acute myocardial infarction−induced myocardial damage via downregulation of early growth response factor 1
样品类型: Serum,Cell culture supernatant - 文献: Changes in alpha-7 nicotinic acetylcholine receptor and macrophage polarization state participate in the regulation of cervical remodeling in pregnant rats
样品类型: Tissue homogenate - 文献: Protective effect of betulinic acid on Freund's complete adjuvant‐induced arthritis in rats
样品类型: serum,synovium - 文献: Nobiletin attenuates acetaminophen‐induced hepatorenal toxicity in rats
样品类型: Serum,Tissue homogenate - 文献: The gut microbiota attenuates muscle wasting by regulating energy metabolism in chemotherapy-induced malnutrition rats
样品类型: Serum,Tissue homogenate,Feces - 文献: Protective effect of apigenin magnesium complex on H2O2-induced oxidative stress and inflammatory responses in rat hepatic stellate cells
样品类型: Cell culture supernatant - 文献: Renoprotective and antioxidative effects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats
样品类型: Serum,Tissue homogenate - 文献: Melatonin ameliorates myocardial injury by reducing apoptosis and autophagy of cardiomyocytes in a rat cardiopulmonary bypass model
样品类型: Plasma - 文献: The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.
样品类型: Serum - 文献: Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation
样品类型: Serum - 文献: Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction
样品类型: plasma - 文献: Examination of protective and therapeutic effects of ruscogenin on cerulein-induced experimental acute pancreatitis in rats
样品类型: Serum,Tissue homogenate - 文献: Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β
样品类型: Serum - 文献: Astragalus polysaccharides combined with ibuprofen exhibit a therapeutic effect on septic rats via an anti‑inflammatory cholinergic pathway
样品类型: Plasma - 文献: Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Rat ModelProtective Effect of Epigallocatechin Gallate
样品类型: serum - 文献: Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation
样品类型: Serum - 文献: Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity
样品类型: Tissue homogenate - 文献: Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway
样品类型: Serum - 文献: Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats
样品类型: brain tissue,serum - 文献: miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4
样品类型: Cell culture supernatant - 文献: Isoproterenol‑mediated heme oxygenase‑1 induction inhibits high mobility group box 1 protein release and protects against rat myocardial ischemia/reperfusion injury in vivo
样品类型: myocardial tissues - 文献: Vanillic Acid Alleviates Right Ventricular Function in Rats With MCT-Induced Pulmonary Arterial Hypertension
样品类型: serum - 文献: The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats
样品类型: Serum - 文献: Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats
样品类型: Lung，kidney - 文献: Mucolytic and Antioxidant Effects of Intranasal Acetylcysteine Use on Acute Rhinosinusitis in Rats with an Acute Rhinosinusitis Model
样品类型: nose,sinuses - 文献: Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism
样品类型: Serum - 文献: Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid
样品类型: Tissue homogenate - 文献: Epigallocatechin Gallate Attenuates Hip Fracture-Induced Acute Lung Injury by Limiting Mitochondrial DNA (mtDNA) Release
样品类型: Bronchoalveolar Lavage Fluid - 文献: Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study
样品类型: Serum - 文献: Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress
样品类型: liver - 文献: Effect of polysaccharides from Vitis vinifera L. on NF-κB/IκB-α signal pathway and inflammatory factors in Alzheimer's model rats
样品类型: Serum - 文献: The effects of chrysin on lipopolysaccharide‐induced sepsis in rats
样品类型: lung,liver,kidney - 文献: Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway
样品类型: Serum - 文献: Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX‑2, TGF‑β1/2, MMP‑9 and BDNF in a rat model
样品类型: intervertebral discs - 文献: Qiliqiangxin Protects against Renal Injury in Rat with Cardiorenal Syndrome Type I through Regulating the Inflammatory and Oxidative Stress Signaling
样品类型: Plasma - 文献: Nelumbo nucifera Gaertn. leaves: network pharmacology and molecular docking analysis of active ingredients and their mechanisms of action in treating atherosclerosis
样品类型: serum - 文献: Candida glabrata induced infection of rat tracheal epithelial cells is mediated by TLR-2 induced activation of NF-κB
样品类型: Cell lysate - 文献: Protective effect of Alpinetin on rats with chronic obstructive pulmonary disease
样品类型: Cell culture supernatant - 文献: MicroRNA‑22 alleviates inflammation in ischemic stroke via p38 MAPK pathways
样品类型: serum - 文献: Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats
样品类型: colonic tissue - 文献: Improvement in post-partum uterine involution in rats treated with Apios americana
样品类型: serum - 文献: Effect of oligosaccharides on the antioxidant, lipid and inflammatory profiles of rats with streptozotocin-induced diabetes mellitus
样品类型: serum - 文献: Mechanism of TangGanJian on nonalcoholic fatty liver disease with type 2 diabetes mellitus
样品类型: serum - 文献: Evaluation of 2 Rat Models for Sepsis Developed by Improved Cecal Ligation/Puncture or Feces Intraperitoneal-Injection
样品类型: Plasma - 文献: Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats
样品类型: hippocampus - 文献: Hyperuricemia Inhibition Protects SD Rats Against Fructose-Induced Obesity Hypertension Via Modulation of Inflammation and Renin-Angiotensin System in Adipose Tissue
样品类型: Serum - 文献: Carob attenuates nicotine-induced oxidative stress and intratesticular damage in male rats
样品类型: serum - 文献: Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats
样品类型: Tissue homogenate - 文献: Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino rats
样品类型: ovarian,thyroid,thyroid cell - 文献: Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model
样品类型: blood - 文献: Silver Nanoparticles Biofabricated from Cinnamomum zeylanicum
Reduce IL-6, IL-18, and TNF-ɑ in Female Rats with
Polycystic Ovarian Syndrome
样品类型: serum - 文献: Production of Inflammatory Mediators in Conditioned Medium of Adipose Tissue-Derived Mesenchymal Stem Cells (ATMSC)-Treated Fresh Frozen Plasma
样品类型: Adipose Tissue-Derived Mesenchymal Stem Cells (ATMSC) - 文献: Polyphenolic-rich extracts of Andrographis paniculata mitigate hyperglycemia via attenuating β-cell dysfunction, pro-inflammatory cytokines and oxidative stress in alloxan-induced diabetic Wistar albino rat
样品类型: serum - 文献: Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines
样品类型: H4IIE cell,clone-9 cell - 文献: Interactions of alcohol and combination antiretroviral (cART) drug in diabetic male Sprague Dawley rats: Hippocampal perturbations and toxicosis
样品类型: brain - 文献: Inflammation-induced left ventricular fibrosis is partially mediated by tumor necrosis factor-α
样品类型: serum - 文献: Highly active antiretroviral therapy conjugated silver nanoparticle ameliorates testicular injury in type-2 diabetic rats
样品类型: testicular tissue - 文献: Effect of Oleanolic acid administration on hepatic AMPK, SIRT-1, IL-6 and NF-κB levels in experimental diabetes
样品类型: Liver tissue - 文献: Anti-inflammatory activity of Xanthium indicum on carrageenan-induced paw edema in rats
样品类型: Tissue homogenate - 文献: Acetate supplementation restores testicular function by modulating Nrf2/PPAR-γ in high fat diet-induced obesity in Wistar rats
样品类型: testicular tissue - 文献: Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway
样品类型: serum - 文献: The effects of vitamin D, fish oil and exercise on cardiovascular parameters in ovariectomized rats
样品类型: serum - 文献: Effect of penehyclidine hydrochloride on IL-6, TNF-α, HIF- 1α and oxidative stress in lung tissue of young rats with acute lung injury
样品类型: Serum - 文献: Protective Effect of Nigella Sativa in an Animal Model of Colon Anastomosis With Ischemia/Reperfusion Injury
样品类型: colon tissue - 文献: Toll-like receptor 7 involves the injury in acute kidney ischemia/reperfusion of STZ-induced diabetic rats
样品类型: Serum - 文献: Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats
样品类型: Serum - 文献: Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.
样品类型: Serum - 文献: Antiinflammatory effects of adalimumab, tocilizumab, and steroid on lipopolysaccharide-induced lung injury
样品类型: bronchoalveolar lavage (BAL)
