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RBM15 Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-18870

宿主: Rabbit

反应性: H

应用: IHC

  • 详情
  • Overview

    Synonyms One twenty two protein,One-twenty two protein 1,OTT,OTT1,Putative RNA-binding protein 15,RBM15,RBM15,RNA binding motif protein 15,RNA-binding motif protein 15,RBM15抗体
    Swissprot Q96T37
    Source Rabbit
    Reactivity Human
    Immunogen Fusion protein of human RBM15
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:50-1:300
    Concentration 1.2mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Nucleus.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
    Background RNA-binding motif protein 15 (RBM15) belongs to the SPEN protein family,which have repressor function in several signaling pathway,and may bind to RNA through interaction with spliceosome components. It was first described as a 5′ translocation partner of the MAL gene in t(1,22)(p13;q13) infant acute megakaryocytic leukemia,and it functions in murine hematopoiesis through modulating Notch-induced transcriptional activation,which play crucial roles in leukemogenesis. Decreasing RBM15 levels with RNA interference could inhibit the growth and proliferation,block the cell cycle,and induce apoptosis in CML cells.
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