Recombinant GSDMD Monoclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1420 / ￥2310 |
货号：E-AB-81473
货期：咨询
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | DF5L,DFNA5L,FKSG10,GSDMDC1,GSDMD,Recombinant Rabbit mAb,Recombinant Rabbit Monoclonal Antibody |
| Swissprot | P57764 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human GSDMD |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:1000; |
| Concentration | 300 μg/mL |
| Clonality | Rabbit Monoclonal |
Properties
| Cellular localization | Cytosol,NLRP3 inflammasome complex,Extracellular region or secreted,extracellular region,extracellular space,Nucleus,nucleoplasm,Plasma Membrane,Other locations:ficolin-1-rich granule lumen,specific granule lumen,tertiary granule lumen |
| Clone No | R06-5C5 |
|---|---|
| Isotype | IgG |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Background | GSDMD is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. GSDMD has been suggested to act as a tumor suppressor. Recently,GSDMD is identified as a new component of inflammasomes,and it is an executor of pyroptosis and required for interleukin-1β secretion. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. |
