RIC8A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19028
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | MGC104517,MGC131931,MGC148073,MGC148074,Protein Ric-8A,resistance to inhibitors of cholinesterase 8 homolog A (C. elegans),RIC8,RIC8A,RIC8A,Synembryn-A,RIC8A抗体 |
| Swissprot | Q9NPQ8 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human RIC8A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 0.96mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Cell membrane. Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
