RITA1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19212
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | C12orf52 ,Chromosome 12 open reading frame 52 ,RBPJ interacting and tubulin associated 1,RBPJ interacting and tubulin associated protein 1,RBPJ-interacting and tubulin-associated protein,RITA,RITA,RITA1抗体 |
| Swissprot | Q96K30 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human RITA1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 1.02mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasm>cytoskeleton>centrosome. Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. |
