RNF111 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18773
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | ARK,Arkadia,DKFZp313E0731,DKFZp686H1966,DKFZp761D081,E3 ubiquitin protein ligase Arkadia,E3 ubiquitin-protein ligase Arkadia,FLJ38008,RING finger protein 111,RN111,RNF 111,RNF111,RNF111抗体 |
| Swissprot | Q6ZNA4 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Fusion protein of human RNF111 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 0.84mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Upon TGF-beta treatment, translocates from nucleus to cytosol. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase.This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription.As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
