ROR1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16872
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | dJ537F10.1,Inactive tyrosine protein kinase transmembrane receptor ROR1,MGC99659,Neurotrophic tyrosine kinase,Neurotrophic tyrosine kinase receptor related 1,Neurotrophic tyrosine kinase,receptor related 1,NTRKR1,OTTHUMP00000010573,OTTHUMP00000010574,OTTMUSP00000008344,Receptor tyrosine kinase like orphan receptor 1,receptor-related 1,RGD1559469,ROR 1,ROR1,ROR1,RP11 24J23.1,Tyrosine kinase like orphan receptor 1,Tyrosine protein kinase transmembrane receptor ROR1,Tyrosine-protein kinase transmembrane receptor ROR1,ROR1抗体 |
| Swissprot | Q01973 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human ROR1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:25-1:100 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Tissue specificity | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. |
