RRAGA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15366
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1,Rag A,RagA,Ras-related GTP-binding protein A,RRAGA,RRAGA,RRAGA抗体 |
| Swissprot | Q7L523 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human RRAGA |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Lysosome. Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. |
| Tissue specificity | Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGAgene.Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB.This is a crucial step in the activation of the TOR signaling cascade by amino acids.Involved in the RCC1/Ran-GTPase pathway.May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. |
