S100A4 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70283
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | 18A2,42A,calcium Placental protein,Calvasculin,CAPL,Fibroblast specific protein 1 (FSP1),Fibroblast specific protein 1,Fibroblast specific protein,FSP1,Leukemia multidrug resistance associated protein,Malignant transformation suppression 1 (MTS1),Malignant transformation suppression 1,Metastasin,MTS1,OTTHUMP00000015467,OTTHUMP00000015468,P9KA,PEL98,Placental calcium-binding protein,Protein Mts1,Protein S100 A4,Protein S100-A4,S100 calcium binding protein A4 (calcium protein,calvasculin,metastasin,murine placental homolog),S100 calcium binding protein A4,S100 calcium-binding protein A4,S100a4,S10A4,S100A4抗体 |
| Swissprot | P26447,P07091,P05942 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Mouse S100A4 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:300-1:800; |
| Concentration | 0.75 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, Nucleus |
| Tissue specificity | Ubiquitously expressed.Highest expression level in synovial joint. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer. |
Images
Western Blot analysis of various samples using S100A4 Polyclonal Antibody at dilution of 1:600.
Immunohistochemistry analysis of paraffin-embedded human lung cancer using S100A4 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of paraffin-embedded Mouse lung using S100A4 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of paraffin-embedded Rat kidney using S100A4 Polyclonal Antibody at dilution of 1:400.
