S100A8 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70341
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | 60B8Ag,AI323541,B8Ag,BEE11,CAGA,Calgranulin-A,Calprotectin L1L subunit,Calprotectin,included,CFAG,CGLA,Chemotactic cytokine CP-10,CP-10,Cystic fibrosis antigen,L1Ag,Leukocyte L1 complex light chain,MA387,MIF,Migration inhibitory factor-related protein 8,MRP-8,Myeloid-related protein 8,Neutrophil cytosolic 7 kDa protein,NIF,p8,Pro-inflammatory S100 cytokine,Protein S100-A8,S100 calcium binding protein A8 (calgranulin A),S100 calcium binding protein A8,S100 calcium-binding protein A8,S100A8,S100A8/S100A9 complex,included,S10A8,Urinary stone protein band A,S100A8抗体 |
| Swissprot | P27005,P50115 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | Recombinant protein corresponding to Mouse S100A8 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 0.8 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. Cytoplasm. Cytoplasm>cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation. |
| Tissue specificity | Highest expression level in bone marrow |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. |
