S100B Polyclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1010 / ￥1640 |
货号：D-AB-10368L
货期：咨询
宿主: Rabbit
反应性: R
应用: IHC
Overview
| Synonyms | NEF,Protein S100 B,Protein S100-B,S 100 calcium binding protein beta chain,S 100 protein beta chain,S-100 protein beta chain,S-100 protein subunit beta,S100,S100 calcium binding protein beta (neural),S100 calcium-binding protein B,S100 protein beta chain,S100B,S100B,S100beta |
| Swissprot | P04631 |
| Source | Rabbit |
| Reactivity | Rat |
| Immunogen | Recombinant Human S100B protein expressed by E.coli |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:2000-1:4700 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. |
| Tissue specificity | Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs and has been implicated in the regulation of cellular activities such as metabolism, motility and proliferation. In the nervous system, S100B is constitutively released by astrocytes into the extracellular space and at nanomolar concentrations, it can promote neurite outgrowth and protect neurons against oxidative stress. Within the central nervous system (CNS), S100B is thought to be a marker for astroglial activation, linking astrocyte dysfunction to schizophrenia. In addition to astrocytes, S100B is released from many cell types, such as, adipocytes, chondrocytes, cardiomyocytes and lymphocytes. Serum S100B represents a new bomarker for mood disorders. |
