SCN11A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16054
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | hNaN,NaN,NAV1.9,Peripheral nerve sodium channel 5,PN 5,PN5,SCN 11A,SCN 12A,Scn11a,SCN12A,SCNBA,Sensory neuron sodium channel 2,SNS 2,SNS2,Sodium channel protein type 11 subunit alpha,Sodium channel protein type XI subunit alpha,Sodium channel voltage gated type XI alpha,Sodium channel voltage gated type XI alpha polypeptide,Sodium channel voltage gated type XI alpha subunit,Sodium channel voltage gated type XII alpha polypeptide,Voltage gated sodium channel Nav1.9,Voltage gated sodium channel subunit alpha Nav1.9,Voltage-gated sodium channel subunit alpha Nav1.9,SCN11A抗体 |
| Swissprot | Q9UI33 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human SCN11A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. |
| Tissue specificity | Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers. |
