SIRT1 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70071
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 75SirT1,hSIR2,hSIRT1,HST2,S. cerevisiae,homolog of,NAD dependent deacetylase sirtuin 1,NAD dependent protein deacetylase sirtuin 1,OTTHUMP00000198111,OTTHUMP00000198112,Regulatory protein SIR2 homolog 1,SIR1,SIR2,SIR2 like 1,SIR2 like protein 1,SIR2,S.cerevisiae,homolog-like 1,SIR2-like protein 1,SIR2ALPHA,SIR2L1,Sirt1,SirtT1 75 kDa fragment,Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae),Sirtuin 1,Sirtuin type 1,SIRT1抗体 |
| Swissprot | Q96EB6,Q923E4,Q96EB6 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse SIRT1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 0.57 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Mitochondrion and Nucleus, PML body. Cytoplasm. Nucleus. Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). |
| Tissue specificity | Widely expressed.Highest expression level in right adrenal gland. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | SIRT1,also named as SIR2L1,contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection,including: activation of endothelial nitric oxide synthase,insulin receptor signalling,and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO,Hif-2a,and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53,specifically at Lysine 382. |
Images
Immunohistochemistry analysis of paraffin-embedded human tonsil using SIRT1 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded mouse testis using SIRT1 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded Rat testis using SIRT1 Polyclonal Antibody at dilution of 1:300.
客户发表文献
- 文献: SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5
样品类型: spinal cord
