SLC4A4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14348
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | DKFZp781H1314,Electrogenic sodium bicarbonate cotransporter 1,hhNMC,HNBC 1,HNBC1,kNBC 1,KNBC,kNBC1,Na(+)/HCO3(-) cotransporter,Na+HCO3- cotransporter 4,NBC 1,NBC 2,NBC1,NBC2,Nbc4,NBCE 1,NBCE1,OTTHUMP00000160355,OTTHUMP00000218884,OTTHUMP00000218885,PNBC,S4A4,SLC4A4,SLC4A5,Sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter,kidney,sodium bicarbonate cotransporter,pancreas),Sodium bicarbonate cotransporter,Sodium bicarbonate cotransporter kidney,sodium bicarbonate cotransporter member 4,Sodium bicarbonate cotransporter pancreas,Solute carrier family 4 member 4,Solute carrier family 4 sodium bicarbonate cotransporter member 4,Solute carrier family 4 sodium bicarbonate cotransporter member 5,Solute carrier family 4,sodium bicarbonate cotransporter,member 4,brain type,SLC4A4抗体 |
| Swissprot | Q9Y6R1 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human SLC4A4 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Basolateral cell membrane. |
| Tissue specificity | Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states. |
