SLC6A4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16233
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 5 HTT,5 HTTLPR,5 hydroxytryptamine (serotonin) transporter,5 hydroxytryptamine transporter,5HT transporter,5HTT,hSERT,HTT,Na+/Cl- dependent serotonin transporter,OCD1,SC6A4,Serotonin transporter 1,SERT,SERT1,Slc6a4,Sodium dependent serotonin transporter,Sodium-dependent serotonin transporter,Solute carrier family 6 (neurotransmitter transporter) member 4,solute carrier family 6 (neurotransmitter transporter,serotonin),member 4,Solute carrier family 6 member 4,SLC6A4抗体 |
| Swissprot | P31645 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human SLC6A4 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Endomembrane system. Endosome membrane. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. |
| Tissue specificity | Expressed in platelets (at protein level). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. |
