SMARCA4 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70117
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | ATP dependent helicase SMARCA4,ATP-dependent helicase SMARCA4,BAF 190,BAF190,BAF190A,Brahma protein like 1,BRG1,BRG1 associated factor 190A,BRG1 protein,BRG1-associated factor 190A,BRM/SWI2 related gene 1,Global transcription activator homologous sequence,global transcription activator snf2l4,Homeotic gene regulator,hSNF2b,Mitotic growth and transcription activator,MRD16,Nuclear protein GRB1,Protein brahma homolog 1,Protein BRG-1,Protein BRG1,RTPS2,SMARC A4,SMARCA4,SMCA4,SNF2,SNF2 beta,SNF2 like 4,SNF2-beta,SNF2B,SNF2L4,SNF2LB,Sucrose nonfermenting like 4,SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4,SWI/SNF related,matrix associated,actin dependent regulator of chromatin,subfamily a,member 4,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4,SWI2,Transcription activator BRG1,SMARCA4抗体 |
| Swissprot | P51532,Q3TKT4,Q8K1P7 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse BRG1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:200-1:600; |
| Concentration | 410 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level).Highest expression level in tendon of biceps brachii. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. |
Images
Western Blot analysis of various samples using SMARCA4 Polyclonal Antibody at dilution of 1:750.
Immunohistochemistry analysis of paraffin-embedded Human tonsil using SMARCA4 Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse testis using SMARCA4 Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat kidney using SMARCA4 Polyclonal Antibody at dilution of 1:200.
