SNCA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16253
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Alpha synuclein,Alpha-synuclein,Alpha-synuclein,isoform NACP140,alphaSYN,MGC105443,MGC110988,MGC127560,MGC64356,NACP,Non A beta component of AD amyloid,Non A4 component of amyloid,Non A4 component of amyloid precursor,Non-A beta component of AD amyloid,Non-A-beta component of alzheimers disease amyloid,precursor of,Non-A4 component of amyloid precursor,Non-A4 component of amyloid,precursor of,OTTHUMP00000218549,OTTHUMP00000218551,OTTHUMP00000218552,OTTHUMP00000218553,OTTHUMP00000218554,PARK 1,PARK 4,PARK1,PARK4,Parkinson disease (autosomal dominant,Lewy body) 4,Parkinson disease familial 1,SNCA,Snca synuclein,alpha (non A4 component of amyloid precursor),SYN,Synuclein alpha,Synuclein alpha 140,Synuclein,alpha (non A4 component of amyloid precursor),SYUA,SNCA抗体 |
| Swissprot | P37840 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human SNCA |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, cytosol. Membrane. Nucleus. Cell junction, synapse. Secreted. Membrane-bound in dopaminergic neurons. |
| Tissue specificity | Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. |
