SNCA Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70302
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | Alpha synuclein,Alpha-synuclein,Alpha-synuclein,isoform NACP140,alphaSYN,MGC105443,MGC110988,MGC127560,MGC64356,NACP,Non A beta component of AD amyloid,Non A4 component of amyloid,Non A4 component of amyloid precursor,Non-A beta component of AD amyloid,Non-A-beta component of alzheimers disease amyloid,precursor of,Non-A4 component of amyloid precursor,Non-A4 component of amyloid,precursor of,OTTHUMP00000218549,OTTHUMP00000218551,OTTHUMP00000218552,OTTHUMP00000218553,OTTHUMP00000218554,PARK 1,PARK 4,PARK1,PARK4,Parkinson disease (autosomal dominant,Lewy body) 4,Parkinson disease familial 1,SNCA,Snca synuclein,alpha (non A4 component of amyloid precursor),SYN,Synuclein alpha,Synuclein alpha 140,Synuclein,alpha (non A4 component of amyloid precursor),SYUA,SNCA抗体 |
| Swissprot | P37840,O55042,P37377 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse α-synuclein |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.92 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, cytosol. Membrane. Nucleus. Cell junction, synapse. Secreted. Membrane-bound in dopaminergic neurons. |
| Tissue specificity | Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.Highest expression level in bone marrow. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. |
