SORBS2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52997
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Arg binding protein 2,Arg-binding protein 2,Arg/Abl interacting protein 2,Arg/Abl interacting protein,Arg/Abl-interacting protein 2,ArgBP2,KIAA0777,PRO0618,sorbin and SH3 domain containing 2,Sorbin and SH3 domain-containing protein 2,Sorbin,Sorbs2,SRBS2,SORBS2抗体 |
| Swissprot | O94875 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human SORBS2 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:5000;IHC,,1:150-1:300; |
| Concentration | 1.62mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium. Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases.They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins.This gene encodes the sorbin and SH3 domain containing 2 protein.It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins.The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton.Alternative splicing results in multiple transcript variants encoding different isoforms. |
Images
Western blot analysis of 231 A549 and LO2 cell lysates using SORBS2 Polyclonal Antibody at dilution of 1:1350
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SORBS2 Polyclonal Antibody at dilution of 1:160(×200)
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using SORBS2 Polyclonal Antibody at dilution of 1:160(×200)
