ST14 Polyclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1010 / ￥1640 |
货号：D-AB-10208L
货期：咨询
宿主: Rabbit
反应性: M,R
应用: WB,IHC
Overview
| Synonyms | Epithin,HAI,Matriptase,Membrane type serine protease 1,Membrane type serine protease,Membrane-type serine protease 1,MT SP1,MT-SP1,MTSP 1,MTSP1,Prostamin,PRSS 14,PRSS14,Serine protease 14,Serine protease TADG 15,Serine protease TADG-15,Serine protease TADG15,SNC 19,SNC19,ST 14,ST14,ST14,Suppression of tumorigenicity 14 (colon carcinoma matriptase epithin),Suppression of tumorigenicity 14 (colon carcinoma),Suppression of tumorigenicity 14,Suppressor of tumorigenicity 14 protein,Suppressor of tumorigenicity protein 14,TADG 15,TADG15,TMPRSS14,Tumor associated differentially expressed gene 15 protein,Tumor-associated differentially-expressed gene 15 protein |
| Swissprot | Q9Y5Y6 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | Recombinant Human ST14 protein expressed by E.coli |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1000; |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane |
| Tissue specificity | Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. |
