STAU2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18765
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 39K2,39K3,DKFZp781K0371,Double stranded RNA binding protein Staufen homolog 2,Double-stranded RNA-binding protein Staufen homolog 2,MGC119606,STAU 2,stau2,STAU2,Staufen (Drosophila, RNA-binding protein) homolog 2,Staufen double-stranded RNA binding protein 2,Staufen homolog 2,Staufen RNA binding protein homolog 2,Staufen, RNA binding protein, homolog 2 (Drosophila),STAU2抗体 |
| Swissprot | Q9NUL3 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human STAU2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:40-1:200 |
| Concentration | 0.78mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Nucleus>nucleolus. Endoplasmic reticulum. Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles.These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures.Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively.The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.Several transcript variants encoding different isoforms have been found for this gene. |
