STIL Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40237
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | DKFZp686O09161,MCPH7,OTTHUMP00000009566,SCL interrupting locus protein,SCL-interrupting locus protein,SCL/TAL1 interrupting locus,SIL,STIL,STIL_HUMAN,TAL 1 interrupting locus protein,TAL-1-interrupting locus protein,STIL抗体 |
| Swissprot | Q15468 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human SCL-interrupting locus protien |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm |
| Tissue specificity | Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with Highest expression in lung cancer. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. |
