Survivin Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14381
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC,ELISA
Overview
| Synonyms | API4,Apoptosis inhibitor 4,Apoptosis inhibitor survivin,Apoptosis inhibitor4,Baculoviral IAP repeat containing 5,Baculoviral IAP repeat containing protein 5,Baculoviral IAP repeat-containing protein 5,BIRC 5,BIRC5,BIRC5,EPR 1,IAP4,Survivin variant 3 alpha,SVV,TIAP,Survivin抗体 |
| Swissprot | O15392 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human Survivin |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA |
| Recommended dilution | WB 1:500-1:2000, IHC 1:25-1:100 |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Chromosome. Chromosome>centromere. Cytoplasm>cytoskeleton>spindle. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes. |
| Tissue specificity | Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Images
Western Blot analysis of A431, Jurkat and hela cell using Survivin Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human colon cancer using Survivin Polyclonal Antibody at dilution of 1:25
Immunohistochemistry of paraffin-embedded Human liver cancer using Survivin Polyclonal Antibody at dilution of 1:25
客户发表文献
- 文献: Revealing the suppressive role of protein kinase C delta and p38 mitogen-activated protein kinase (MAPK)/NF-κB axis associates with lenvatinib-inhibited progression in hepatocellular carcinoma in vitro and in vivo
样品类型: Huh7 cell,Hep3B cell - 文献: Fluoxetine Induces Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits ERK/NF-κB-Modulated Anti-Apoptotic and Invasive Potential in Hepatocellular Carcinoma Cells In Vitro
样品类型: Tissue - 文献: Apoptosis induction and AKT/NF-κB inactivation are associated with regroafenib-inhibited tumor progression in non-small cell lung cancer in vitro and in vivo
样品类型: CL1-5-F4 cells
