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TBP Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-18293

宿主: Rabbit

反应性: H

应用: WB

  • 详情
  • Overview

    Synonyms GTF2D,GTF2D1,HDL4,SCA17,TATA binding factor,TATA box binding protein,TATA box factor,TATA sequence binding protein,TATA sequence-binding protein,TATA-binding factor,TATA-box factor,TATA-box-binding protein,TBP,TBP,TFIID,Transcription initiation factor TFIID TBP subunit,TBP抗体
    Swissprot P20226
    Source Rabbit
    Reactivity Human
    Immunogen Full length fusion protein
    Application WB(Detection kit: E-IR-R304)
    Recommended dilution WB,,1:500-1:2000;
    Concentration 0.8mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Nucleus.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
    Background The TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence TATA box. This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP,along with a variety of TBP-associated factors,make up the TFIID,a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex. As one of the few proteins in the preinitation complex that binds DNA in a sequence-specific manner,it helps position RNA polymerase II over the transcription start site of the gene. However,it is estimated that only 10-20% of human promoters have TATA boxes. Therefore,TBP is probably not the only protein involved in positioning RNA polymerase II. This antibody detects human TBP (~40 kDa) and mouse/rat Tbp (~35 kDa).
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