TIMP2 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3580 |
货号：E-AB-60338
宿主: Rabbit
反应性: H,M,R
应用: WB,IF
Overview
| Synonyms | TIMP2,CSC-21K,DDC8,TIMP2抗体 |
| Swissprot | P16035 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human TIMP2 (NP_003246.1). |
| Application | WB(Detection kit: E-IR-R304),IF |
| Recommended dilution | WB,, 1:500-1:2000;IF,, 1:50-1:200; |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20°C. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Background | This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. |
Images
Western blot analysis of extracts of various cell lines using TIMP2 Polyclonal Antibody at dilution of 1:1000.
Immunofluorescence analysis of C6 cells using TIMP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U-2 OS cells using TIMP2 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
