TIMP-2/TIMP2 Polyclonal Antibody
| 规格： | / 25μL / 100μL |
| 价格： | / ￥800 / ￥2100 |
货号：D-AB-10444L
货期：咨询
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | Metalloproteinase inhibitor 2;CSC-21K;Tissue inhibitor of metalloproteinases 2 (TIMP-2);TIMP2 |
| Swissprot | P16035 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Human TIMP-2/TIMP2 protein expressed by E.coli |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:1000 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% BSA and 50% glycerol,pH7.4 |
| Background | Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family,TIMP-1,TIMP-2,TIMP-3,and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types,which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid-potentiating and cell growth promoting activities. |
