TNF RI/TNFRSF1A Polyclonal Antibody(Capture/Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN000820P
货期：咨询
宿主: Rabbit
反应性: H
应用: ELISA Capture/Detector
Overview
| Synonyms | TNF-R;TNF-R-I;TNF-R55;TNFAR;TNFR1;TNFR1-d2;TNFR55;TNFR60;p55;p55-R;p60;CD120a;FPF;MS5;TBP1; |
| Swissprot | P19438 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human TNF RI/TNFRSF1A protein expressed by Mammalian |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | Tumor necrosis factor (TNF) is a multifunctional cytokine that plays a key role in regulating inflammation,immune functions,host defense,and apoptosis . TNF exists in soluble and membrane-bound forms. TNF signals through two distinct cell surface receptors,TNFR1 (TNFRSF1A,CD120a) and TNFR2 (TNFRSF1B,CD120b). Whereas TNFR1 is widely expressed,expression of TNFR2 is limited to cells of the immune system,endothelial cells,and nerve cells . TNFR1,which contains a death domain (DD) within its intracytoplasmic region,is thought to be the key receptor for TNF signaling . This receptor can activate NF-kappaB,mediate apoptosis,and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor,and thus play regulatory roles in the signal transduction mediated by the receptor. |
