TNNI3 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70275
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | cardiac muscle,Cardiac troponin I,cardiomyopathy,dilated 2A (autosomal recessive),Cardiomyopathy,familial hypertrophic,7,included,CMD1FF,CMD2A,CMH7,cTnI,Familial hypertrophic cardiomyopathy 7,MGC116817,RCM1,Tn1,Tni,TNN I3,TNNC 1,TNNC1,TNNI3,TNNI3,Troponin I,Troponin I cardiac,Troponin I cardiac muscle,Troponin I cardiac muscle isoform,Troponin I type 3 cardiac,troponin I,cardiac 3,TroponinI,Ttroponin I type 3 (cardiac),TNNI3抗体 |
| Swissprot | P19429,P48787,P23693 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Cardiac Troponin I |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 140 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoskeleton,cardiac Troponin complex,troponin complex,Cytosol,Other locations:cardiac myofibril,sarcomere |
| Tissue specificity | Highest expression level in apex of heart |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). |
