TRIM21 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15410
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | 52 kDa ribonucleoprotein autoantigen Ro/SS-A,52 kDa Ro protein,52kD Ro/SSA autoantigen,Autoantigen Ro/SSA,52-KD,E3 ubiquitin-protein ligase TRIM21,RING finger protein 81,RNF81,Ro 52,Ro(SS-A),Ro52,RO52,Sicca syndrome antigen A,Sjoegren syndrome type A antigen,Sjogren syndrome antigen A1,Sjogren syndrome type A antigen,SS-A,SSA,SSA1: Sjogren syndrome antigen A1 (52kDa ribonucleoprotein autoantigen SS-A/Ro),TRIM21,Tripartite motif protein TRIM21,Tripartite motif-containing 21,Tripartite motif-containing protein 21,TRIM21抗体 |
| Swissprot | P19474 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human TRIM21 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:1000-1:5000; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasm>P-body. Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body. |
| Tissue specificity | Isoforms 1 and 2 are expressed in fetal and adult heart and fetal lung. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the tripartite motif (TRIM) family.The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules.The RoSSA particle localizes to both the cytoplasm and the nucleus.RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. |
