TTR Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22254
宿主: Mouse
反应性: H
应用: WB,IHC-p
Overview
| Synonyms | Amyloid polyneuropathy,Amyloidosis I,ATTR,Carpal tunnel syndrome 1,CTS,CTS1,Dysprealbuminemic euthyroidal hyperthyroxinemia,Dystransthyretinemic hyperthyroxinemia,Epididymis luminal protein 111,HEL111,HsT2651,PALB,Prealbumin amyloidosis type I,Prealbumin,Prealbumin Thyroxine-binding,Senile systemic amyloidosis,TBPA,Thyroxine binding prealbumin,Transthyretin,TTHY,TTR,TTR protein,TTR Mouse (2B12)抗体 |
| Swissprot | P02766 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Recombinant Protein of TTR |
| Application | WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | WB 1:500-2000, IHC 1:50-300 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Secreted. Cytoplasm. |
| Tissue specificity | Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. |
| Clone No | Clone:2B12 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Background | This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. |
