UMOD Polyclonal Antibody
| 规格： | / 50μL / 100μL |
| 价格： | / ￥1010 / ￥1640 |
货号：D-AB-10364L
货期：咨询
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | ADMCKD2,FJHN,HNFJ,HNFJ1,MCKD2,medullary cystic kidney disease 2 (autosomal dominant),Tamm Horsfall glycoprotein,Tamm Horsfall urinary glycoprotein,Tamm-Horsfall urinary glycoprotein,THGP,THP,Umod,Urehd1,urehr4,UROM_HUMAN,uromodulin (uromucoid, Tamm-Horsfall glycoprotein), Uromodulin |
| Swissprot | P07911 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human UMOD protein expressed by E.coli |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:200 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Secreted. |
| Tissue specificity | Synthesized by kidney. Most abundant protein in normal human urine. |
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. |
