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UNC45B Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-18510

宿主: Rabbit

反应性: H,M

应用: WB

  • 详情
  • Overview

    Synonyms Cardiomyopathy associated 4 ,CMYA4 ,FLJ38610,MGC119540,MGC119541,OTTHUMP00000163855,Protein unc 45 homolog B,Protein unc-45 homolog B,SMUNC45,Striated muscle UNC45,UN45B,Unc 45 homolog B (C. elegans),Unc 45 homolog B,UNC 45B,UNC-45B,UNC45 ,UNC45B,UNC45B抗体
    Swissprot Q8IWX7
    Source Rabbit
    Reactivity Human, Mouse
    Immunogen Fusion protein of human UNC45B
    Application WB(Detection kit: E-IR-R304)
    Recommended dilution WB,,1:500-1:2000;
    Concentration 0.8mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Cytoplasm>cytosol.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
    Background This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.
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