UNC45B Polyclonal Antibody
规格: | / 20μL / 60μL / 120μL / 200μL |
价格: | / ¥420 / ¥1010 / ¥1640 / ¥2365 |
货号:E-AB-18510
宿主: Rabbit
反应性: H,M
应用: WB
Overview
Synonyms | Cardiomyopathy associated 4 ,CMYA4 ,FLJ38610,MGC119540,MGC119541,OTTHUMP00000163855,Protein unc 45 homolog B,Protein unc-45 homolog B,SMUNC45,Striated muscle UNC45,UN45B,Unc 45 homolog B (C. elegans),Unc 45 homolog B,UNC 45B,UNC-45B,UNC45 ,UNC45B,UNC45B抗体 |
Swissprot | Q8IWX7 |
Source | Rabbit |
Reactivity | Human, Mouse |
Immunogen | Fusion protein of human UNC45B |
Application | WB(Detection kit: E-IR-R304) |
Recommended dilution | WB,,1:500-1:2000; |
Concentration | 0.8mg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | Cytoplasm>cytosol. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Background | This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. |