USP12 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18513
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | Deubiquitinating enzyme 12,OTTHUMP00000042337,UBH 1,UBH1,Ubiquitin carboxyl terminal hydrolase 12,Ubiquitin carboxyl-terminal hydrolase 12,Ubiquitin hydrolyzing enzyme 1 ,Ubiquitin specific peptidase 12,Ubiquitin specific processing protease 12,Ubiquitin specific protease 12 like 1,Ubiquitin thioesterase 12,Ubiquitin thiolesterase 12,Ubiquitin-hydrolyzing enzyme 1,Ubiquitin-specific-processing protease 12,UBP12,USP 12,Usp12,USP12L1,USP12抗体 |
| Swissprot | O75317 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.6mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP12 (ubiquitin specific peptidase 12), also known as UBH1 or USP12L1, is a 370 amino acid protein belonging to the peptidase C19 family and the USP12/USP46 subfamily. Considered a deubiquitinating enzyme, it is suggested that USP12 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have high activity. The gene encoding USP12 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. |
