VGLL1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53198
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | Protein TONDU,TDU,TONDU,Transcription cofactor vestigial like protein 1,Transcription cofactor vestigial-like protein 1,Vestigial like 1,vestigial like 1 homolog (Drosophila),Vgl-1,VGL1,Vgll1,VGLL1,VGLL1抗体 |
| Swissprot | Q99990 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human VGLL1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:2000-1:10000 |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay. |
