VRK1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-52422
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | MGC117401,MGC138280,MGC142070,PCH1,PCH1A,Serine/threonine protein kinase VRK1,Serine/threonine-protein kinase VRK1,Vaccinia related kinase 1 ,Vaccinia virus B1R related kinase 1,Vaccinia-related kinase 1,VRK1,VRK1,VRK1抗体 |
| Swissprot | Q99986 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human VRK1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.5mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas.Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination.This gene, therefore, may regulate cell proliferation.This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. |
