XPC Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53352
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | DNA repair protein complementing XP C cells,DNA repair protein complementing XP-C cells,DNA repair protein complementing XPC cells ,p125,RAD4,Xeroderma pigmentosum complementation group C,Xeroderma pigmentosum group C complementing protein,Xeroderma pigmentosum group C protein,Xeroderma pigmentosum group C-complementing protein,Xeroderma pigmentosum group III,XP 3,XP C,XP group C,XP3,Xpc,XPC gene,XPC,XPCC,XPC抗体 |
| Swissprot | Q01831 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human XPC |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:30-1:150 |
| Concentration | 0.66mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Cytoplasm. Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. |
