ZFP42 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16185
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | hREX-1,Reduced Expression 1 Protein,Reduced expression protein 1,Rex-1,REX1,REX1 transcription factor,Zfp-42,Zfp42,ZFP42 zinc finger protein,ZFP42,Zinc finger protein 42 homolog,Zinc finger protein 754,ZNF754,ZFP42抗体 |
| Swissprot | Q96MM3 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human ZFP42 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.2 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Rex-1 (for reduced expression), also designated zinc finger protein 42 (ZFP42), is an acidic zinc finger protein. Rex-1 contains four repeats of the zinc finger nucleic acid-binding motif and a potential acidic activator domain, suggesting that it is a regulatory protein. Rex-1 localizes to the nucleus and is highly expressed in embryonic stem (ES) and undifferentiated murine F9 teratocarcinoma cells. At the transcriptional level, expression of Rex-1 is reduced when F9 cells are induced to differentiate by the addition of retinoic acid (RA), and Rex-1 repression is enhanced by E1A. The Oct-3/4 transcription factor can either activate or repress the Rex-1 promoter, depending on the cellular environment, while Oct-6 can lower the expression of Rex-1. |
